Protein Alignment Rph and tcb3

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_593974.1
• Gene: tcb3 / 2542267
• PomBaseID: SPAPYUK71.03C
• Length: 1225
• Species: Schizosaccharomyces pombe
• Alignment Length: 627
• Identity: 124/627 - (19%)
• Similarity: 187/627 - (29%)
• Gaps: 235/627 - (37%)

  Fly   156 GLPKYDMPRSASATPIPN--------PGPGSMAGDTRAVQSCHATPT-RPARVKKLTI------- 204
            |...|||...|   .:|:        .|||.:.......:.....|: ||....||.|
pombe   545 GRLNYDMKFHA---VVPDSGEEITKVDGPGVLQFTVHQCKELSNDPSKRPTAYAKLIINNKEVYT 606

  Fly   205 ------RVNDSSSSSSGHSEPEDEVDTGVGIGV---------GVVGGGMAKGIASTR-------L 247
                  ..|.|...|.|...||.:..| :|:.:         |.....:....|:|:       |
pombe   607 TRKIKKNNNPSWEESFGTLLPEGKNAT-LGVQIFTEESEHPFGTANVSLQDLFAATKTGLLWFPL 670

  Fly   248 QREDSFRLR----------------------AYGSIRSFIDGGERKLSNSFFFNRQQSQRP-SEC 289
            |...|.|:|                      ..|:||..:...          |...|:.| .:|
pombe   671 QHAPSGRVRMSVMWKPAQLNNDSISSMALATPIGAIRIHLRSA----------NNLHSKIPGKKC 725

  Fly   290 PEYDSVSMSKLRRESSFLRRGSVSSSW-----------------SISDSSGSGSN---------- 327
            ..|..:.....::..:.:...:|:..|                 .:.:.:.||.:
pombe   726 DSYARIMSHNTKQFRTVVIASNVNPFWDEYMYAPVITKHDIFFLQVMNYNSSGEDKLIGQTPINI 790

  Fly   328 ----NSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEI----AISYREAFHSLDCTMVRARDLPAMD 384
                |.|.:....:|...::     ...||.....|    .|:::..|.....|...:.|:....
pombe   791 SNFINQGENGALMEYHDPRE-----LTVPLSSTRGIKGNATITFKCDFFPSAVTTSLSPDVTPAP 850

  Fly   385 AAGLADPYCKLNI-ITPEAHTKYTRWQRTKTVH-----KTRNPE-----------FNETLQFVGV 432
            .|.......|:|| :.||:....|....|.|..     ||..|:           .|..|.|
pombe   851 KASSTVATDKVNIEVLPESQKTPTAVDNTSTSRGSTSVKTSKPKKISELLMPSEAVNAALDF--- 912

  Fly   433 EPEELGNSLI---------YVALFDDDKYGHDFLGAA---------------------------- 460
            |...:|..:|         .:|:|.||...|.||.:|
pombe   913 ESGFMGFDIISYKIAKPAQELAIFLDDLPHHIFLSSALNVTGGATLHEYGNTFIRQLEYSQCTFK 977

  Fly   461 ----------KVCLS----TVHSTSQYRISVPLGVE-----------------DQYSNAAEMAQN 494
                      |..||    :..:|....|:.|.|..                 :.|.|..||
pombe   978 LLDGDKEVGSKTMLSRDLISKGATKPLEIAFPDGASILVAFRLTPVPVKLEEVEMYENMGEM--- 1039

  Fly   495 WPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLK-PDAHKNKKHKTSVKWRT 558
                               .|:|.:..:|.|.|:||.|||||..:|: .:.::.|.||     ||
pombe  1040 -------------------TVDVIKATDLPAADSNGKSDPFVVFELQGEEVYRTKTHK-----RT 1080

  Fly   559 LNPIYNEEFYFE-ASPHDLNKEMLILTVWDKDLGKSNDFLGS 599
            |||.:||.|..| ......|   .:..|:|.|.|..:|.|||
pombe  1081 LNPTFNESFEVELPCKQTCN---FVANVFDWDFGNKDDHLGS 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	5/15 (33%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	36/194 (19%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	34/103 (33%)
tcb3	NP_593974.1	COG5038	1..1225	CDD:227371	124/627 (20%)