Protein Alignment Rph and Sytl5

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_808372.1
• Gene: Sytl5 / 236643
• MGIID: 2668451
• Length: 753
• Species: Mus musculus
• Alignment Length: 780
• Identity: 172/780 - (22%)
• Similarity: 284/780 - (36%)
• Gaps: 224/780 - (28%)

  Fly    34 SKTSE-----PLRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHA---VERGPNCCRL 90
            ||.||     .|...|:|.|:.|::|:|.::..|.:|:.:|...:.:.|:.:   .:.....|..
Mouse     2 SKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTHQEASRVCVH 66

  Fly    91 CGDTFGILRPQRILCEDCRQSVCTKCSV---DINIRYHTSERSREIWLCRICSETREMWKKSGAW 152
            |..|.|::..:...|:.|...||::|.|   |.:            |.|.:|::..::...||.|
Mouse    67 CHKTLGLIFDRGDPCQACSLRVCSECRVTGLDGS------------WKCTVCAKVAQLRIISGEW 119

  Fly   153 FFKGLPK---------------------------------------------------YDMP--- 163
            |.:...|                                                   :|.|
Mouse   120 FLEEKAKRFKQVNVLGTDVVRQSILRRSPGSEETQNQEQAQQCVDKSDTLSSVRQKTTHDGPKKK 184

  Fly   164 -------RSAS----ATPIPNPGPG-SMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGH 216
                   |||:    .||.|..|.. |:..|::.:||                 ...:|.|..|.
Mouse   185 GFLLSKFRSATRGEIRTPKPESGRSYSLDLDSQNLQS-----------------FKSASGSDRGS 232

  Fly   217 SEPEDEVDTGVG--IGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFN 279
            :...|.:|...|  ........|   ||..|  ||.......:..||.|...|.|..::.:...|
Mouse   233 TTSSDLIDQEAGRRTSKSSYSNG---GIPVT--QRSPVPSAHSVTSINSREHGFENSMALATIEN 292

  Fly   280 ----------RQQSQRPSECPEYDSVSMSKLRRE-------------SSFLRRGS---------- 311
                      |..|..||......|:|..:.|.|             :|.:|..|
Mouse   293 TCEELTKSHRRNTSGTPSIAVSGTSLSSERSRSEVDLSESFAEDLEDTSSIRSRSVPGALDKDLN 357

  Fly   312 -----------VSSSWSI---SDSSGSGSNNSGNSQTQSQY----------------QQHQQQLQ 346
                       |||.:|.   |.:||..:|:...|..:..|                .....:..
Mouse   358 SLEDTEDGVDLVSSRFSANTHSLASGLSTNSQAGSDRKRSYLNVPDADSDTTSLNSMMSVYSETG 422

  Fly   347 QHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMD-AAGLADPYCKLNIITPEAHTKYTRWQ 410
            .:....:.|.:.:.|||......|...:...|:|...| .....|.|.| :.:.|:.    :|..
Mouse   423 DYGNVKVTGEILLHISYCYKTGGLYIFVKSCRNLATGDEKKQRTDAYVK-SYLLPDK----SRNN 482

  Fly   411 RTKTVHKT-RNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTS-- 471
            :.||..:| .||||||||::. :...:|....:.::::..|::| :.|||..::...:.:..:
Mouse   483 KRKTKIRTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIAFDSWNFENPC 546

  Fly   472 ------QYRISVPLGVEDQYSNAAEMAQNW---------PNGKMLLSLCYNTKRR---------A 512
                  |.::.:...:..||.....:...:         |.|:......:...::         .
Mouse   547 DEWFVLQPKVELAPDISLQYKGELTIVLRYIPPEENLIFPAGQRQEKKIFKRGKKKESSSISGGI 611

  Fly   513 LVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEA-SPHDL 576
            |.|.:|:..||.|:.:.|:||.|||..|.||.:|..||||:|..:::||.:|..|.|.. .|.|:
Mouse   612 LEVFIKKAKNLTAVKSGGTSDSFVKGYLLPDDNKATKHKTAVVKKSVNPEWNHTFIFSGLYPQDI 676

  Fly   577 NKEMLILTVWDKDLGKSNDFLGSLQLGA---QSKGERLQQWLDCIRLPDHFHEK--WHCLAPDNP 636
            ....|.||:|||:...||.|||.::|.:   .|.|:.: .|:|     .|..|:  |..:| |||
Mouse   677 KNACLELTIWDKEAFSSNVFLGGVRLNSGSGMSYGKTV-DWMD-----SHGEEQRLWQKMA-DNP 734

  Fly   637  636
            Mouse   735  734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	26/155 (17%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	31/133 (23%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	47/146 (32%)
Sytl5	NP_808372.1	PHD_SF	11..123	CDD:473978	29/123 (24%)
		FYVE_Slp5	62..108	CDD:277305	14/57 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..279		28/155 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	297..359		11/61 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..404		5/23 (22%)
		C2A_SLP-4_5	430..553	CDD:175995	30/128 (23%)
		C2B_SLP_1-2-3-4	567..745	CDD:175987	53/175 (30%)