DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and SYT11

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_016856248.1	Gene:	SYT11 / 23208	HGNCID:	19239	Length:	434	Species:	Homo sapiens

Alignment Length:	416	Identity:	106/416 - (25%)
Similarity:	168/416 - (40%)	Gaps:	89/416 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 QQSQRPSECPEYDSVSM-----------------SKLRR-------------------ESSFLRR 309
            ||:::..:.|.|..:.|                 .|:||                   |:..|.|
Human    42 QQAEKKQKNPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGPGREGGRRNLLVDAAEAGLLSR 106

  Fly   310 ---------GSVSSSWSISDSSGS------GSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEI 359
                     ||......|....|.      .|...|.|:|.|.....:        |.:||.|..
Human   107 DKDPRGPSSGSCIDQLPIKMDYGEELRSPITSLTPGESKTTSPSSPEE--------DVMLGSLTF 163

  Fly   360 AISYREAFHSLDCTMVRARDLPAMD--AAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPE 422
            ::.|.....:|..|:..|..||.||  ..| :|||.|:.|:..:.|.     .:|:.:.||.:|.
Human   164 SVDYNFPKKALVVTIQEAHGLPVMDDQTQG-SDPYIKMTILPDKRHR-----VKTRVLRKTLDPV 222

  Fly   423 FNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLGAAKVCLSTVH-STSQYRIS---VPLGVE 482
            |:||..|.|:...:|.:.:::..:...|::.. |.:|...|.|:.|. ||.:.:::   :...::
Human   223 FDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQLTRDIIKRNIQ 287

  Fly   483 DQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSS----DPFVKIQLKPD 543
            ...|          .|::.:||.|....:.:.|.|.:..:|..||..|.|    ||:||:.:...
Human   288 KCIS----------RGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGRAPDPYVKVNVYYG 342

  Fly   544 AHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLI-LTVWDKDLGKSNDFLGSLQLGAQS- 606
            ..:..|.||.||..|||||:||.|.::. |.||..::.| ..|.|.|....|:.:|.|.|||.|
Human   343 RKRIAKKKTHVKKCTLNPIFNESFIYDI-PTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSV 406

  Fly   607 KGERLQQWLDCIRLPDHFHEKWHCLA 632
            .....:.|.:....|.....|||.|:
Human   407 TASGAEHWREVCESPRKPVAKWHSLS 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	36/129 (28%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	46/137 (34%)
SYT11	XP_016856248.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910