DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rph and RPH3A

DIOPT Version :9

Sequence 1:NP_572651.1 Gene:Rph / 32002 FlyBaseID:FBgn0030230 Length:638 Species:Drosophila melanogaster
Sequence 2:NP_001137326.1 Gene:RPH3A / 22895 HGNCID:17056 Length:694 Species:Homo sapiens


Alignment Length:722 Identity:244/722 - (33%)
Similarity:368/722 - (50%) Gaps:132/722 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 NNTANKFVCPSDRQLALRAK--LKAGWS--------SSKTSEPLRPEEQEAIISVIRRNEEIEVA 61
            :|::|:::.||||.|....|  |:||||        ..:..|.|..||:|.|..||.|.|::|..
Human     7 SNSSNRWMYPSDRPLQSNDKEQLQAGWSVHPGGQPDRQRKQEELTDEEKEIINRVIARAEKMEEM 71

  Fly    62 ERQRVGRLVERVEKIKQHAVERGPNCCRLCGDTFGILRPQRILCEDCRQSVCTKCSVDINIRYHT 126
            |::|:||||:|:|.::::....|.|.|.|||:..|:|....::||||:::|||||.|:.|.|.|:
Human    72 EQERIGRLVDRLENMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVETNNRLHS 136

  Fly   127 SERSREIWLCRICSETREMWKKSGAWFFKGLPKYDMPR----------------SASATPIPNP- 174
                  :|||:||.|.||:||:||||||||.||..:|:                :|...|.|.| 
Human   137 ------VWLCKICIEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQPVSEPAAPEQPAPEPK 195

  Fly   175 ---------------GPGSMAGDTRAV---QSCHATPTRPARVKKLTIRVNDSSSSSSGHSEPED 221
                           |||...|...|.   :..:..|.|.|...::        ||||..||..|
Human   196 HPARAPARGDSEDRRGPGQKTGPDPASAPGRGNYGPPVRRASEARM--------SSSSRDSESWD 252

  Fly   222 EVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLR--AYGSIRS---------FIDGGERKLSNS 275
            .           .||......:...|:|.:|.:..  |.||::|         ...||.|.....
Human   253 H-----------SGGAGDSSRSPAGLRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGP 306

  Fly   276 FFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSG-NSQTQSQY- 338
              ..|...|:|...|. |..:.:..|.|    |.|.|....::.......|:.|| .||..:.. 
Human   307 --AGRFPDQKPEVAPS-DPGTTAPPREE----RTGGVGGYPAVGAREDRMSHPSGPYSQASAAAP 364

  Fly   339 -----------QQHQQQLQQHCRD--PLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLAD 390
                       ::.:::...:..|  ..||.||.::.|.:...||.||:::|:.|..||:.||||
Human   365 QPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLAD 429

  Fly   391 PYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH- 454
            ||.||::: |.| :|..: .||||:..||||.:||||.:.|:..|::....:.:::.|:||:|| 
Human   430 PYVKLHLL-PGA-SKSNK-LRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHN 491

  Fly   455 DFLGAAK---------------VCLSTV------HSTSQYRISVPLGVEDQYSNAAEMAQNWPNG 498
            :|:|..:               :||..|      .:|...| .:.|..|:|.....::.:   .|
Human   492 EFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSAR-GMALYEEEQVERVGDIEE---RG 552

  Fly   499 KMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIY 563
            |:|:||.|:|::..|:|.:.:|::|.|||.||.||||||:.||||..|..||||.:|.:||||.:
Human   553 KILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEF 617

  Fly   564 NEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKW 628
            ||||:::....||.|:.|.::|||.|:|||||::|..|||..:|||||:.|.:|::..|...|:|
Human   618 NEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERW 682

  Fly   629 HCLAPDN 635
            |.|..:|
Human   683 HQLQNEN 689

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RphNP_572651.1 PHD_SF 84..172 CDD:304600 44/103 (43%)
C2A_Rabphilin_Doc2 354..477 CDD:176000 50/144 (35%)
C2B_Rabphilin_Doc2 499..631 CDD:176030 67/131 (51%)
RPH3ANP_001137326.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51 14/43 (33%)
FYVE_RP3A 92..171 CDD:277301 42/84 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 166..388 47/247 (19%)
C2A_Rabphilin_Doc2 393..516 CDD:176000 45/125 (36%)
C2B_Rabphilin_Doc2 553..685 CDD:176030 67/131 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 129 1.000 Domainoid score I5247
eggNOG 1 0.900 - - E1_KOG1013
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7921
Inparanoid 1 1.050 352 1.000 Inparanoid score I2269
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46624
OrthoDB 1 1.010 - - D185575at33208
OrthoFinder 1 1.000 - - FOG0000025
OrthoInspector 1 1.000 - - otm40625
orthoMCL 1 0.900 - - OOG6_106212
Panther 1 1.100 - - O PTHR45729
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2745
SonicParanoid 1 1.000 - - X85
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.870

Return to query results.
Submit another query.