DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and Syt4

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_033334.2	Gene:	Syt4 / 20983	MGIID:	101759	Length:	425	Species:	Mus musculus

Alignment Length:	313	Identity:	86/313 - (27%)
Similarity:	145/313 - (46%)	Gaps:	28/313 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 SGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGL 388
            :.|..|..|.|....::.|::         ||.|.:::.|.....:....:..|:.|||||...:
Mouse   133 ANSPESLKSSTSLTSEEKQEK---------LGTLFLSLEYNFEKKAFVVNIKEAQGLPAMDEQSM 188

  Fly   389 -ADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKY 452
             :|||.|:.|:..:.|.     .:|:.:.||.:|.|:||..|.|:....:....::..:...|::
Mouse   189 TSDPYIKMTILPEKKHR-----VKTRVLRKTLDPVFDETFTFYGIPYPHIQELSLHFTVLSFDRF 248

  Fly   453 GH-DFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVN 516
            .. |.:|...:.||.:..:....:   :..|....||.:.:   ..|::|:||||.:....|.|.
Mouse   249 SRDDVIGEVLIPLSGIELSDGKML---MTREIIKRNAKKSS---GRGELLVSLCYQSTTNTLTVV 307

  Fly   517 VKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFE---ASPHDLNK 578
            |.:..:|...|.:|.|||:||:.|.....:..|.||.||..|.|.::||.|.|:   .|..:::.
Mouse   308 VLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIPCESLEEISV 372

  Fly   579 EMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCL 631
            |.|:|   |.:.|..|:.:|.|.|||.::|.....|.:....|.....|||.|
Mouse   373 EFLVL---DSERGSRNEVIGRLVLGATAEGSGGGHWKEICDFPRRQIAKWHML 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	30/124 (24%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	46/134 (34%)
Syt4	NP_033334.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..147		4/13 (31%)
		C2A_Synaptotagmin-4-11	153..279	CDD:176034	31/142 (22%)
		C2B_Synaptotagmin-4	288..423	CDD:176049	48/138 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910