Protein Alignment Rph and Syt2

DIOPT Version :9

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001342655.1
• Gene: Syt2 / 20980
• MGIID: 99666
• Length: 422
• Species: Mus musculus
• Alignment Length: 487
• Identity: 125/487 - (25%)
• Similarity: 212/487 - (43%)
• Gaps: 110/487 - (22%)

  Fly   172 PNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHSEPEDEVDTGVGIGVGVVGG 236
            ||..|.:    |.|...  ..|..||          |:|:.|:|..|
Mouse    11 PNVAPAT----TTATMP--LAPVAPA----------DNSTESTGPGE------------------ 41

  Fly   237 GMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKL- 300
                       .:||.|                .||...||  .:.::.|  .|.:..::|:.:
Mouse    42 -----------SQEDMF----------------AKLKEKFF--NEINKIP--LPPWALIAMAVVA 75

  Fly   301 -----------------RRESSFLRRG-SVSSSWSISD-SSGSGSNNSGNSQTQSQYQQHQQQLQ 346
                             :::.:...:| .:.::.::.| ..|...:::....|:.:.:..:::..
Mouse    76 GLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEP 140

  Fly   347 QHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQR 411
            ::     ||.|:.::.|....:.|...:::|.:|||:|..|.:|||.|: .:.|:...||    .
Mouse   141 EN-----LGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKV-FLLPDKKKKY----E 195

  Fly   412 TKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYRI 475
            ||...||.||.||||..| .|..:|||...:.:|::|.|::. ||.:|..||.::||.      :
Mouse   196 TKVHRKTLNPAFNETFTF-KVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVD------L 253

  Fly   476 SVPLGVEDQYSNAAEMAQNWPN--GKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKI 538
            ..|:   :::.:.....:..|.  |.:..||.|......|.|.:.:..||..||..|.|||:|||
Mouse   254 GQPI---EEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKI 315

  Fly   539 QLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKD-LGKSNDFLGSLQL 602
            .|..:..:.||.||:||.:||||.:||.|.||.....:.|..:::||.|.| ||| |:.:|.:.:
Mouse   316 HLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGK-NEAIGKIFV 379

  Fly   603 GAQSKGERLQQWLDCIRLPDHFHEKWHCLAPD 634
            |:.:.|..|:.|.|.:..|.....:||.|.|:
Mouse   380 GSNATGTELRHWSDMLANPRRPIAQWHSLKPE 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	125/487 (26%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	43/123 (35%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	50/132 (38%)
Syt2	NP_001342655.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		13/76 (17%)
		Syt2_N	4..116	CDD:409249	25/169 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..141		4/38 (11%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		89/266 (33%)
		C2A_Synaptotagmin-1-5-6-9-10	142..264	CDD:176031	44/141 (31%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	51/135 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910