DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and Rph3a

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_011246487.1	Gene:	Rph3a / 19894	MGIID:	102788	Length:	684	Species:	Mus musculus

Alignment Length:	720	Identity:	228/720 - (31%)
Similarity:	355/720 - (49%)	Gaps:	134/720 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NNTANKFVCPSDRQLALRAK--LKAGWS--------SSKTSEPLRPEEQEAIISVIRRNEEIEVA 61
            :...|:::.|.|..|....|  |:||||        ..:..|.|..||:|.|..||.|.|::|..
Mouse     3 DTVVNRWMYPGDGPLQSNDKEQLQAGWSVHPGAQTDRQRKQEELTDEEKEIINRVIARAEKMEAM 67

  Fly    62 ERQRVGRLVERVEKIKQHAVERGPNCCRLCGDTFGILRPQRILCEDCRQSVCTKCSVDINIRYHT 126
            |::|:||||:|:|.::::....|.|.|.|||:..|:|....::||||:::|||||.|:.     :
Mouse    68 EQERIGRLVDRLETMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVET-----S 127

  Fly   127 SERSREIWLCRICSETREMWKKSGAWFFKGLPKYDMPR----------------SASATPIP--- 172
            :.|...:|||:||.|.||:||:||||||||.||..:|:                :....|.|
Mouse   128 NNRPHPVWLCKICLEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQPAGEPATQEQPTPESR 192

  Fly   173 -------------------NPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHSE 218
                               .|||...:...|   ..|..|||.|...:::....||......|
Mouse   193 HPARAPARGDMEDRRPPGQKPGPDLTSAPGR---GSHGPPTRRASEARMSTAARDSEGWDHAH-- 252

  Fly   219 PEDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSF------------------- 264
                            |||  .|..|.....|..  ||...|:::.
Mouse   253 ----------------GGG--TGDTSRSPAGEQG--LRRANSVQAARPAPAPVPSPAPPQPVQPG 297

  Fly   265 IDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNS 329
            ..||.|.......|..|.::.|...|.|.. :::..|.|     |...:..:..:..:.:..:.:
Mouse   298 PPGGSRATPGPGRFPEQSTEAPPSDPGYPG-AVAPAREE-----RTGPAGGFQAAPHTAAPYSQA 356

  Fly   330 GNSQTQSQYQQHQQQLQQHCRD--PLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPY 392
            ..::.....::.:::...:..|  ..||.||.::.|.:...:|.||::||:.|..||:.||||||
Mouse   357 APARQPPPAEEEEEEANSYDSDEATTLGALEFSLLYDQDNSNLQCTIIRAKGLKPMDSNGLADPY 421

  Fly   393 CKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DF 456
            .||::: |.| :|..: .||||:..||||.:|||||:.|:..|::....:.:::.|:||:|| :|
Mouse   422 VKLHLL-PGA-SKSNK-LRTKTLRNTRNPVWNETLQYHGITEEDMQRKTLRISVCDEDKFGHNEF 483

  Fly   457 LGAAK---------------VCLSTV------HSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKM 500
            :|..:               :||..|      .:|...| .:.|..|:|.....::.:   .||:
Mouse   484 IGETRFSLKKLKANQRKNFNICLERVIPMKRAGTTGSAR-GMALYEEEQVERIGDIEE---RGKI 544

  Fly   501 LLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNE 565
            |:||.|:|::..|:|.:.:|::|.|||.||.||||||:.||||..|..||||.:|.:||||.:||
Mouse   545 LVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNE 609

  Fly   566 EFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHC 630
            ||:::....||.|:.|.::|||.|:|||||::|..|||..:|||||:.|.:|::..|...|:||.
Mouse   610 EFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQ 674

  Fly   631 LAPDN 635
            |..:|
Mouse   675 LQNEN 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	41/103 (40%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	51/144 (35%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	67/131 (51%)
Rph3a	XP_011246487.1	FYVE_RP3A	88..168	CDD:277301	40/84 (48%)
		PRK07764	<175..352	CDD:236090	34/207 (16%)
		C2A_Rabphilin_Doc2	383..506	CDD:176000	46/125 (37%)
		C2B_Rabphilin_Doc2	543..675	CDD:176030	67/131 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5346
eggNOG	1	0.900	-	-		E1_KOG1013
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7921
Inparanoid	1	1.050	348	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46624
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm42701
orthoMCL	1	0.900	-	-		OOG6_106212
Panther	1	1.100	-	-	O	PTHR45729
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2745
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860