DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and sue-1

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_492083.2	Gene:	sue-1 / 184108	WormBaseID:	WBGene00006306	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	518	Identity:	104/518 - (20%)
Similarity:	171/518 - (33%)	Gaps:	110/518 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 PKYDMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRP----------ARVKKLTIRVNDSSSS 212
            |...:.||:|...:|.|.|  ::.:.|...:......||          |.:..||...::...:
Worm    28 PDTHLRRSSSPRILPTPPP--LSPEYRCPSAAPHLERRPSGRQLPRPPTAELSNLTSLAHNGPGN 90

  Fly   213 SSGHSEP----------------EDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSI 261
            |.....|                |::||....:..........:|.....::.||...:.....|
Worm    91 SQCSLSPVSLTPDPTPDEPEFYEEEDVDESEVVEEDYAQEEEEEGDDGEVVEYEDPVVVTPPEEI 155

  Fly   262 RSFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSG- 325
                    |::|.....          .|......|||....|..:.:.:..||....|....|
Worm   156 --------RRISPEILI----------APPPQPRRMSKFSVHSPSIEQITSKSSSDTEDPIAHGL 202

  Fly   326 --------------SNNSGNSQTQ--SQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTM 374
                          :||:...:|.  |......||.:.      ||.|..::.|......|..|:
Worm   203 DPSLYSPNAPIIIENNNTAIHKTSVASSSSPTPQQPRG------LGLLHCSLLYFAVRKRLRVTV 261

  Fly   375 VRARDL-----PAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEP 434
            .:...|     |.|:...|    ||::|...:...     ::|....:.|:|.||....|..|..
Worm   262 TKIEALAGELKPEMEIHAL----CKVSIPGLKGGK-----EQTSETKRGRDPLFNHEFFFDNVTH 317

  Fly   435 EELGNSLIYVALFDDD---KYGHDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWP 496
            |||...::.:......   |.....:|.|.|.|..:..         :..:.:.....|:....|
Worm   318 EELDTKVVIITACHAGGGIKGKEIVIGEASVPLRDIRE---------MNTKKEIKFIEEIKGLVP 373

  Fly   497 N--GKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTL 559
            .  ||:..|.......:.|.:|:|:...|......|:.|..|||.|...|....|....:| .|.
Worm   374 KKLGKIYTSSIIEKDSKRLTINLKKVDALPKCGLIGAPDVCVKITLTQGAKTQTKSSRVIK-NTC 437

  Fly   560 NPIYNEEFYF--EASPHDLNKEMLILTVWDKDLGKSND------FLGSLQLGAQSKGERLQQW 614
            :.:|||...|  ..|.:||.:..::::|.|.....:.|      :||   :||..|.| :.||
Worm   438 SAVYNEAVMFLCGTSKNDLAQTSIVISVHDAQRTCTGDDTIGCAYLG---IGAVDKSE-IDQW 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	4/13 (31%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	28/130 (22%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	34/124 (27%)
sue-1	NP_492083.2	C2	242..349	CDD:301316	25/115 (22%)
sue-1	NP_492083.2	C2	389..513	CDD:301316	32/113 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910