DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and snt-6

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_001254022.1	Gene:	snt-6 / 182427	WormBaseID:	WBGene00004926	Length:	373	Species:	Caenorhabditis elegans

Alignment Length:	358	Identity:	88/358 - (24%)
Similarity:	158/358 - (44%)	Gaps:	29/358 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 QRPSECPEYDSVSMSKLRRESSFLRRGSVS-SSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQ 347
            ::|.:..|.|....::|.|........:|. .|..:..|..:..:.|.|....|...|.:.::..
Worm    35 RKPVDIDELDCEQTARLFRPEVLAPTLTVDMESRKVQPSLKARLSQSINPWKTSIIDQLRPEVVS 99

  Fly   348 HCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRT 412
            ..|    |.:..::::.:...:|...::.|.|||..|..|.:|||.:..::.....:     :|:
Worm   100 EFR----GRINFSVAFEKECSTLHVHLMEAVDLPVKDFTGSSDPYVRAFLLQDPGQS-----ERS 155

  Fly   413 KTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGHDF-LGAAKVCLSTV--HSTSQY- 473
            |...:..||.|||||.|.|...::|.:..:.:.:.|.|::..|. :|...:.|..|  .|:..|
Worm   156 KVHRRNLNPTFNETLSFRGHSMKKLHDMTLVLQVMDYDRFSSDDPIGEILLPLKHVKFESSPVYW 220

  Fly   474 -RISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVK 537
             .:..|...:|..            |::::||||......:.|::.:..:|.|.|.....|.:||
Worm   221 KHLQRPTVSKDAC------------GEIMISLCYLPTSGKITVSIIKARDLHAKDRTRHYDTYVK 273

  Fly   538 IQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHD--LNKEMLILTVWDKDLGKSNDFLGSL 600
            :.:....:|.:|.|||||..|.:||:||.|.|......  |.:..|:||..:.|:..||:.:|.:
Worm   274 MWMVQQGNKLEKRKTSVKPHTPSPIFNESFAFSIPVKQVLLAEVNLVLTAMEYDVIGSNEEIGHV 338

  Fly   601 QLGAQSKGERLQQWLDCIRLPDHFHEKWHCLAP 633
            .:|........:.|.:|:..|:.....||.|.|
Worm   339 IVGGLGSEHGQRHWSECVNHPEQPVAMWHKLCP 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	31/127 (24%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	39/133 (29%)
snt-6	NP_001254022.1	C2	101..225	CDD:387358	32/132 (24%)
snt-6	NP_001254022.1	C2B_Synaptotagmin	234..369	CDD:175975	40/134 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910