DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and snt-5

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_503409.1	Gene:	snt-5 / 178631	WormBaseID:	WBGene00004925	Length:	458	Species:	Caenorhabditis elegans

Alignment Length:	431	Identity:	110/431 - (25%)
Similarity:	177/431 - (41%)	Gaps:	103/431 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 SQRPSECPEY--------DSVSMSKLR--RESSFLRRGSVSSSW--------------------S 317
            |:.|:..||.        .::|:||:.  ..:..|.|...|..|                    |
Worm    43 SEVPTSVPEIKVSVPQSASTLSISKMNGSYRARVLSRNGCSPPWMDRNFETSTRSSPCTSPAIAS 107

  Fly   318 ISDS---------SGSGSNNS-------GNSQTQSQYQQHQQQLQQH------------CRDPLL 354
            .|||         |.|...||       ||.:...:.:...::...|            |   :.
Worm   108 TSDSCELLGDDPRSASSMRNSMFLFNVDGNPEVIDEMEDIDERSVMHYELGFYDKTDGGC---IR 169

  Fly   355 GWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPE--AHTKYTRWQRTKTVHK 417
            |.|..|:.|......|...::||.:||..|.....|||.|:.:: ||  .|.|      |:...|
Worm   170 GTLTFALRYDFIHRVLMLHVIRANNLPVEDKGVTVDPYVKMYLL-PERRGHCK------TRICKK 227

  Fly   418 TRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKY-GHDFLGAAKVCL------STVHSTSQYRI 475
            |.:|||||...| .|....|.|.::...::|.|:: .|..:|  .:.:      |.:::.::|.:
Worm   228 TNDPEFNEMFSF-DVSFNNLANRMLQFTVYDFDRFTRHGLIG--NIIMRDLFEKSDLYTWTEYTM 289

  Fly   476 SVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQL 540
            .:   |..|..|        ..|.:||.|.|:.:...|.:||.:..||..||..|:|||:|||:.
Worm   290 HI---VASQNKN--------DYGDLLLFLTYSNQEEKLYINVSKAYNLRPMDITGASDPYVKIEQ 343

  Fly   541 KPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTV--WDKDLGKSNDFLGSLQLG 603
            ..:..:.|..|:|.|...|||:::|...|:.....:.:..:::.|  ||: :|| :|.||...||
Worm   344 TFNGKRFKSKKSSTKRANLNPVFHETLVFDIPSSQIAETNILIQVMDWDR-IGK-DDLLGCCILG 406

  Fly   604 AQS-KGERLQQWLDCIR-LPDHFHEK------WHCLAPDNP 636
            ..| ..:...||.:|:. :|:....|      ||.|..:.|
Worm   407 KDSPTADGKTQWDNCLNAVPEEGQLKNKPVGQWHSLLSEVP 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	36/131 (27%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	45/141 (32%)
snt-5	NP_503409.1	C2	169..277	CDD:301316	34/117 (29%)
snt-5	NP_503409.1	C2B_Synaptotagmin	301..442	CDD:175975	46/142 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910