Protein Alignment Rph and rbf-1

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001367825.1
• Gene: rbf-1 / 175943
• WormBaseID: WBGene00004316
• Length: 1123
• Species: Caenorhabditis elegans
• Alignment Length: 956
• Identity: 232/956 - (24%)
• Similarity: 354/956 - (37%)
• Gaps: 340/956 - (35%)

  Fly     9 TANKFVCPSDRQLALRAKLKAGWS-----------SSKTSEPLRPEEQEAIISVIRRNEEIEVAE 62
            |.||:||||||.|.|||:||:|||           |...:..:...|||.|..|:.:.||.:..|
 Worm   179 TQNKWVCPSDRHLHLRAQLKSGWSVRTATARSPTNSKAQTGSITAAEQEHIQKVLAKAEESKSKE 243

  Fly    63 RQRVGRLVERVEKIKQHAVERGPNCCRLCGDTFGIL--RPQRILCEDCRQSVCTK-CSVDINIRY 124
            :||:|::|:|:||:::.|...|...|.||...||:|  :....:|.|||:.||.: |.|:.....
 Worm   244 QQRIGKMVDRLEKMRRRATGNGVTHCLLCHTEFGLLASKSYAAMCVDCRKYVCQRNCGVETTDVN 308

  Fly   125 HTSERSREIWLCRICSETRE-MWKKSGAWFFKGLPKYDMP------------------RSASATP 170
            .|:.:...::||:||||.|| :||||||||:|.:|::..|                  .|::|||
 Worm   309 QTTGKVETVFLCKICSEAREVLWKKSGAWFYKEMPEFQRPDDRLPYYVPVTTNGTLPNASSAATP 373

  Fly   171 I--------PNP-------------------------------GP-------------------- 176
            :        |.|                               ||
 Worm   374 LSGTPGGAGPQPMTMPSTSSCQMTTPKWASPGVCNSPGLQMNGGPTSPLPNGTRRNTGHGGIEFP 438

  Fly   177 -------------------------------------GSMA------------------------ 180
                                                 .||:
 Worm   439 SSSRPSICSVLQAIEPLDRSKSPRPRIQPRWVNEKVMSSMSVDDEEKAASSSDGESFVQSGVPRR 503

  Fly   181 --------GDTRAVQS-----CHATPT--RPARVKKLT---------IRVNDSSSSSSGHSEPED 221
                    |.|.|..|     ...|||  |.|.:::.:         :...|....||..|.|..
 Worm   504 ALNNKTPVGSTSATTSPAPPPTSTTPTSRREANMERFSRHTHAHANRLYSTDDDDDSSPESRPST 568

  Fly   222 EV-------------------DTGV------GIGVGVV--------------------------- 234
            ..                   ||.:      .|..|||
 Worm   569 RSTSPRHSLATPSSYAHDTCHDTSLPDADTRSIDSGVVQSDHSNPQQSGLTCSSSSLTPLQQQAS 633

  Fly   235 -----GGGMAKGIA-------------------------STRLQRE--DSFRLRAY----GSIRS 263
                 |||..:.|:                         |:|...:  :|..|...    .|..:
 Worm   634 HDHHSGGGTPRRISNPDRTTSRVAQSASGTSLVTPPPPISSRTSPDNCNSSPLNVMEHKSSSAST 698

  Fly   264 FIDGGERK-------LSNSFFFNRQQSQRP--SECPEYDSVSMSKLRRESSFL------------ 307
            ...||.|:       |:|....:..|:...  .:.....|.:.|.|...||||
 Worm   699 ASSGGNRRVGSAEPVLNNHHAMHNNQNHNDINKKLISQTSRAESPLAASSSFLSSPDDDTKQKNR 763

  Fly   308 RRGSVSSSWS----------------ISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPL--- 353
            ||..|....|                ||..:|...::...|.|.|.        |.|...|:
 Worm   764 RRDGVGRVNSLQLRTSLDDVAPPVAPISKMNGHIVSSEPTSSTTSN--------QNHTSVPIPTV 820

  Fly   354 ------------------------LGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCK 394
                                    ||.:.:.::|..|...|...::||::|.|||:.|.:|||.|
 Worm   821 PVVPEEEEEKAITASTESASEPGSLGSITLTLTYHSADKKLKMHLIRAKNLKAMDSNGFSDPYVK 885

  Fly   395 LNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGHDFLGA 459
            .:::  ..:||.|: ..:||:.||.|||:||.:.:.|:..::....::.|.:.|.|:.|.||||.
 Worm   886 FHLL--PGNTKATK-LTSKTIEKTLNPEWNEEMSYYGITEDDKEKKILRVTVLDRDRIGSDFLGE 947

  Fly   460 AKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLM 524
            .::.|..::.....:.::.|..........:..:|...||:.:.|.||.::.:|.:|:.:|:.|:
 Worm   948 TRIALKKLNDNEMKKFNLYLESALPVPQQTKEEENEDRGKINVGLQYNIQQGSLFININRCVELV 1012

  Fly   525 AMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKD 589
            .||:.|.|||:.|:.|.|...|..:.|||.|.|||||.:||:..|.....||.|:.|.:.|:|.|
 Worm  1013 GMDSTGFSDPYCKVSLTPITSKAHRAKTSTKKRTLNPEWNEQLQFVVPFKDLPKKTLQIGVYDHD 1077

  Fly   590 LGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCLAPDN 635
            |||.:|::|.:.|...:|.||.:||:.||..|....|.||.|..|:
 Worm  1078 LGKHDDYIGGILLSTSAKDERGRQWIKCIENPGTLVEAWHRLELDS 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	39/117 (33%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	38/122 (31%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	54/131 (41%)
rbf-1	NP_001367825.1	FYVE_2	219..342	CDD:426716	49/122 (40%)
		C2A_Rabphilin_Doc2	845..967	CDD:176000	38/124 (31%)
		C2B_Rabphilin_Doc2	987..1119	CDD:176030	54/131 (41%)