DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and snt-1

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_495394.3	Gene:	snt-1 / 174120	WormBaseID:	WBGene00004921	Length:	443	Species:	Caenorhabditis elegans

Alignment Length:	354	Identity:	104/354 - (29%)
Similarity:	163/354 - (46%)	Gaps:	46/354 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 RRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQ----YQQHQQQLQQHCRDPLLGWLEIAI 361
            :|.....::|.:...:........|.|..|.:|...:    .:|::::..:...:..||.::..:
Worm   103 KRHGEKNKKGGLKGFFGKGQDVVDGKNIQGMAQDLEELGDAMEQNEKEQAEEKEEVKLGRIQYKL 167

  Fly   362 SYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNET 426
            .|......|..|:::|.|||.||.:|.:|||.||.:: ||...|.    .||...||.||.||||
Worm   168 DYDFQQGQLTVTVIQAEDLPGMDMSGTSDPYVKLYLL-PEKKKKV----ETKVHRKTLNPVFNET 227

  Fly   427 LQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAE 490
            ..|.....|....:|:: |::|.|::. ||.:|               ::.:|||..|    ...
Worm   228 FIFKVAFNEITAKTLVF-AIYDFDRFSKHDQIG---------------QVLIPLGKID----LGA 272

  Fly   491 MAQNWPN--------------GKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQL- 540
            :.:.|.:              |.:..||.|......|.|.:.:..||..||..|.|||:||:::
Worm   273 VIEEWKDIAPPPDDKEAEKSLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKLEMF 337

  Fly   541 KPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASP-HDLNKEMLILTVWDKDLGKSNDFLGSLQLGA 604
            ..|..:.||.||::|.:||||.:||.|.|:..| |.:.|..|::||.|.|...|||.:|...||.
Worm   338 GEDRKRLKKKKTNIKRKTLNPYFNESFVFDKLPLHKMKKVSLMITVMDYDKLGSNDAIGRCLLGC 402

  Fly   605 QSKGERLQQWLDCIRLPDHFHEKWHCLAP 633
            ...|..|:.|:|.:..|.....:||.|.|
Worm   403 NGTGAELRHWMDMLASPRRPIAQWHTLGP 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	39/123 (32%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	50/133 (38%)
snt-1	NP_495394.3	C2A_Synaptotagmin-1-5-6-9-10	160..282	CDD:176031	44/146 (30%)
snt-1	NP_495394.3	C2B_Synaptotagmin-1	293..429	CDD:176047	51/135 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910