DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and snt-4

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_491853.2	Gene:	snt-4 / 172346	WormBaseID:	WBGene00004924	Length:	381	Species:	Caenorhabditis elegans

Alignment Length:	457	Identity:	109/457 - (23%)
Similarity:	162/457 - (35%)	Gaps:	141/457 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 SSSSGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSI----RSFI------ 265
            :.|:||    :....|||..||:........:.:.|.:|:       |.|:    |..|
Worm     9 AKSAGH----EWFYLGVGGAVGLAALVAVAALLAVRKRRQ-------YPSLLLPPRQVIAVRGGF 62

  Fly   266 ---DGG--------ERKLSN-----------SFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLR 308
               .||        :..|||           :...:|.:...|||.|.                .
Worm    63 PKGPGGLKQSPSPLQSPLSNDSTPSPVVPLQNLLEDRTRKLSPSELPS----------------E 111

  Fly   309 RGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCT 373
            ||::|.:.|                    |..|...|           |...|:.|..     |.
Worm   112 RGNISFTLS--------------------YDSHTLTL-----------LVSIINCRNL-----CE 140

  Fly   374 MVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELG 438
            ||.:|     |...|.|||.||.::....|.     .:|:.|..|.:|.:.|.....||..|::.
Worm   141 MVVSR-----DGQCLLDPYVKLQLLPEREHR-----VKTRIVRSTTSPVYEEQFAMYGVTHEQVN 195

  Fly   439 NSLIYVALFDDDKYGHDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWP------- 496
            .:.::..:...|:|..|          ||.....||::   ..|.|..|  ||....|
Worm   196 FATLHFQVVAFDRYSRD----------TVVGECVYRLA---DAELQVHN--EMRVELPLLPRATD 245

  Fly   497 ----NGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQL-KPDAHKNKKHKTSVKW 556
                .|::||||.|......|.|.|.:...|...::.|::|||||:.| |....:..|.:|.|:.
Worm   246 TVAARGELLLSLTYQAAFNNLTVVVLKARGLGGRNDAGTADPFVKLYLRKESGERIVKKRTHVRR 310

  Fly   557 RTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLG---------AQSKGERLQ 612
            .||||:|||.|.||.....|...::.|.|.:.|....||.:|...|.         .::.|.::.
Worm   311 STLNPVYNESFVFELPDDRLEHSVIDLQVINHDRVNRNDVIGRALLNMEDSHVVEVLENPGRQVA 375

  Fly   613 QW 614
            ||
Worm   376 QW 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	30/122 (25%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	41/126 (33%)
snt-4	NP_491853.2	C2A_Synaptotagmin-4-11	111..241	CDD:176034	43/190 (23%)
snt-4	NP_491853.2	C2	250..381	CDD:301316	42/128 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910