Protein Alignment Rph and SYT6

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001353153.1
• Gene: SYT6 / 148281
• HGNCID: 18638
• Length: 528
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 87/278 - (31%)
• Similarity: 146/278 - (52%)
• Gaps: 13/278 - (4%)

  Fly   355 GWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTR 419
            |.:..::.|.....:|...:::|.||||.|..|.:|||.|:.:: |:...|.    :|:...||.
Human   231 GKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLL-PDRKCKL----QTRVHRKTL 290

  Fly   420 NPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVED 483
            ||.|:|...| .|..|||.:..:::::||.|::. ||.:|  :|.|..:...|.......:..:.
Human   291 NPTFDENFHF-PVPYEELADRKLHLSVFDFDRFSRHDMIG--EVILDNLFEASDLSRETSIWKDI 352

  Fly   484 QYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNK 548
            ||:.    :::...|:::.||||......|.:.|.:|.||.|||..|.|||:||:.|..|..:.|
Human   353 QYAT----SESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLK 413

  Fly   549 KHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQ 613
            |.||::|..||||:|||...|:..|.::::..|:::|.|.|....|:.:|..::|..::|.....
Human   414 KKKTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEGLGRDH 478

  Fly   614 WLDCIRLPDHFHEKWHCL 631
            |.:.:..|......||.|
Human   479 WNEMLAYPRKPIAHWHSL 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710
		C2A_Rabphilin_Doc2	354..477	CDD:176000	37/122 (30%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	46/131 (35%)
SYT6	NP_001353153.1	Cysteine motif. /evidence=ECO:0000250|UniProtKB:O35681	12..38
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..178
		C2A_Synaptotagmin-1-5-6-9-10	230..354	CDD:176031	37/130 (28%)
		C2B_Synaptotagmin-3-5-6-9-10	363..496	CDD:176048	47/132 (36%)