Protein Alignment Rph and Sytl4

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_536335.2
• Gene: Sytl4 / 140594
• RGDID: 620204
• Length: 672
• Species: Rattus norvegicus
• Alignment Length: 677
• Identity: 162/677 - (23%)
• Similarity: 265/677 - (39%)
• Gaps: 159/677 - (23%)

  Fly    44 EQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHAVERG-----PNCCRLCGDTFGILRPQRI 103
            |::.|:||::|:||:..|:.:|:.||...:.:||:...:||     ...|..|.:..|.|..:..
  Rat    14 ERDLILSVLQRDEELRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQEGLGRLISKSN 78

  Fly   104 LCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFF-------------- 154
            .|..|...||.:|.|         ..|...|.|::||:..|:.|.:|.||:
  Rat    79 TCVGCNHLVCRECRV---------LESNGSWRCKVCSKEIELKKATGDWFYDQKVNRFAYRTGSD 134

  Fly   155 ------KGLPKYDMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVN------ 207
                  :..|..:...:...:.:.....|.:....|.:|......:....|.||....:
  Rat   135 IIRMSLRRKPAVNKRETVGQSLLQQTQMGDIWPGRRIIQEQQKEQSVLFEVPKLKSGKSALEAES 199

  Fly   208 --------DSSSSS-------SG-------HSEPEDEVDTGVGIG-----VGVVGGGMAKGIAST 245
                    ||.|:|       ||       .|.|:.:|:..:..|     .|..|..:.|  .:|
  Rat   200 ESLDSYTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKEIAPGNQNAVCGDEGDMIFK--KNT 262

  Fly   246 RLQREDSFRLRAYGSIR-------SFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRE 303
            |.....|...::...:|       |.|.|...|.......:.::.:...|    |...:.||.|:
  Rat   263 RKVLRPSEYTKSVIDLRPEDVAQESGILGDRSKSVPGLSVDMEEEEEEEE----DIDHLVKLHRQ 323

  Fly   304 SSFLRRGSVSSSWSIS---------DSSGSGSNNS--GNSQTQSQYQQHQQQLQQHCRDPLLGWL 357
            .  |.|||:.|..|:|         ..:|...|.|  |......:::|..|.|
  Rat   324 K--LARGSMQSGSSMSTIGSMMSLYSEAGDFGNVSVTGKIAFSLKFEQKTQTL------------ 374

  Fly   358 EIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPE 422
                    ..|..:|..:...|    :|...::||.|..:: |:...:..|  :|.....|.||.
  Rat   375 --------VIHVKECHQLAYAD----EAKKRSNPYVKTYLL-PDKSRQGKR--KTSIKRDTINPL 424

  Fly   423 FNETLQFVGVEPEELGNSL-----IYVALFDDDKYGHD-FLGAAKVCLSTVHSTSQYRISVPLGV 481
            ::||.::      |:..||     :..:::...::|.: |||.|:|.:.:.....:....:||
  Rat   425 YDETFRY------EISESLLAQRTLQFSVWHHGRFGRNTFLGEAEVHMDSWKLDKKLDHCLPL-- 481

  Fly   482 EDQYSNAAEMAQNWP--NGKMLLSLCY---------NTKRRA-------LVVNVKQCINLMAMDN 528
              ....:.|.:...|  .|::::||.|         ..::::       |.|.:|:..||.|..:
  Rat   482 --HGKISTESSPGLPAHKGELVVSLKYIPASKLPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKS 544

  Fly   529 NGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEF-YFEASPHDLNKEMLILTVWDKDLGK 592
            .|:||.|||..|.|..:|..|.||.|..:||||.||..| |......||....|.|||||::...
  Rat   545 GGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLA 609

  Fly   593 SNDFLGSLQLGAQ---SKGERLQQWLD 616
            ||||||.::||..   |.|| :..|:|
  Rat   610 SNDFLGGVRLGVGTGISSGE-VVDWMD 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	22/112 (20%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	24/128 (19%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	51/138 (37%)
Sytl4	NP_536335.2	PHD_SF	8..121	CDD:473978	35/115 (30%)
		FYVE_Slp4	58..107	CDD:277303	14/57 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	199..222		4/22 (18%)
		C2A_SLP-4_5	358..482	CDD:175995	30/160 (19%)
		C2B_SLP_1-2-3-4	497..662	CDD:175987	52/140 (37%)