DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and Doc2b

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_031899.2	Gene:	Doc2b / 13447	MGIID:	1100497	Length:	412	Species:	Mus musculus

Alignment Length:	285	Identity:	120/285 - (42%)
Similarity:	180/285 - (63%)	Gaps:	7/285 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 LGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKT 418
            ||.|:.::.|.:..::|.||:.:|:.|..||..||||||.||::: |.| :|..: .||||:..|
Mouse   127 LGTLDFSLLYDQENNALHCTISKAKGLKPMDHNGLADPYVKLHLL-PGA-SKANK-LRTKTLRNT 188

  Fly   419 RNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLGAAKVCLSTVHSTSQYRISVPLGVE 482
            .||.:||||.:.|:..|::....:.:::.|:||:.| :|:|..:|.|..:........|:.|  |
Mouse   189 LNPSWNETLTYYGITDEDMVRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICL--E 251

  Fly   483 DQYS-NAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHK 546
            .|.. :.||.......|::|:||.|:::::.|:|.:.:|.:|.|||.||.|||:||..||||..|
Mouse   252 KQLPVDKAEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDK 316

  Fly   547 NKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERL 611
            ..||||:||.:||||.:||||.:|....||.|:.|.:||||.|:||||||:|.:.||..:|||||
Mouse   317 KSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGINAKGERL 381

  Fly   612 QQWLDCIRLPDHFHEKWHCLAPDNP 636
            :.|.||::..|...|:||.|..:.|
Mouse   382 KHWFDCLKNKDKRIERWHTLTNELP 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	43/123 (35%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	68/131 (52%)
Doc2b	NP_031899.2	Mediates interaction with DYNLT1. /evidence=ECO:0000250	1..90
		Negatively regulates targeting to plasma membrane	1..36
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..123
		C2A_Rabphilin_Doc2	127..250	CDD:176000	44/125 (35%)
		Mediates interaction with STXBP3. /evidence=ECO:0000269\|PubMed:17548353	257..375		59/117 (50%)
		C2B_Rabphilin_Doc2	269..401	CDD:176030	68/131 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5346
eggNOG	1	0.900	-	-		E1_KOG1013
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	348	1.000	Inparanoid score	I2281
Isobase	1	0.950	-	0	Normalized mean entropy	S4254
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185575at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm42701
orthoMCL	1	0.900	-	-		OOG6_106212
Panther	1	1.100	-	-	O	PTHR45729
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.810