Protein Alignment Rph and Syt4

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_321260.4
• Gene: Syt4 / 1281315
• VectorBaseID: AGAMI1_010967
• Length: 480
• Species: Anopheles gambiae
• Alignment Length: 539
• Identity: 129/539 - (23%)
• Similarity: 195/539 - (36%)
• Gaps: 142/539 - (26%)

  Fly   136 CRICSETREMWKKSGAWFFKGLPKYDMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRPARVK 200
            |......|...||:|             ..||:.|...|.|      .:||:|....|  |..:|
Mosquito    39 CFCARRFRRQHKKAG-------------HEASSLPFQPPRP------PKAVRSPSGQP--PQYLK 82

  Fly   201 KLTIRVNDSSSSSS-----GH---SEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRA 257
            |       |.|.:|     ||   ..|.|:.         ...||.....|:|.|....
Mosquito    83 K-------SPSPTSIKPLPGHLPAQSPTDQT---------TAAGGTTAATATTTLATTT------ 125

  Fly   258 YGSIRSFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSS 322
              :..|.:...:....|.......|.:     |:...||                    .:.|.|
Mosquito   126 --TTTSIVPPTKYTEENELIPKNAQLE-----PKSPDVS--------------------ELGDPS 163

  Fly   323 GSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMD--- 384
            .. .|..|.               :|.:   ||.:...:.:.....:|..::||.|.||..:
Mosquito   164 AC-ENGDGT---------------EHGK---LGTIVFKLRFLADRSALVVSVVRCRGLPGKNHGT 209

  Fly   385 -AAGLA--------------------DPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQ 428
             ||.|:                    |||.||.::..:.|.     .:|:.:..||||.::|...
Mosquito   210 AAAELSTIGGGTMLCNGSANGKQTATDPYVKLQLLPDKQHK-----VKTRVLRNTRNPVYDEDFT 269

  Fly   429 FVGVEPEELGNSLIYVALFDDDKYGHDFLGAAKVC-LSTVHSTSQYRISVPLGVEDQYSNAAEMA 492
            |.|:...||....::..:...|:|..|.:....|| ||.:.........|.|..|.|..:....|
Mosquito   270 FYGLTLSELAGMSLHFVVLSFDRYSRDDVIGEVVCPLSGIDLQQIENQQVALSREIQPRSLKIRA 334

  Fly   493 QNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWR 557
            |.  .|::|:|||:......|.|.:.:..||..||..|.:||:|||.|..:..:..|.||.||.|
Mosquito   335 QG--RGELLISLCWQPAAARLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKR 397

  Fly   558 TLNPIYNEEFYFE---------ASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGA-QSKGERLQ 612
            ||:|::||.|.|:         |:...::.|:::|. ||:  ...|:.:|.|:||. :|.|..|.
Mosquito   398 TLSPVFNESFAFDIPTTEGAGGATLDGVSLELMLLD-WDR--VTKNEVIGRLELGGPRSNGSALN 459

  Fly   613 QWLDCIRLPDHFHEKWHCL 631
            .|.:....|......||.|
Mosquito   460 HWKEVCNSPRRQIADWHKL 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	8/35 (23%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	34/147 (23%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	47/141 (33%)
Syt4	XP_321260.4	C2A_Synaptotagmin-4-11	175..327	CDD:176034	37/159 (23%)
		C2B_Synaptotagmin-4	337..479	CDD:176049	49/145 (34%)