DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and SYT2

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_016855798.1	Gene:	SYT2 / 127833	HGNCID:	11510	Length:	479	Species:	Homo sapiens

Alignment Length:	334	Identity:	103/334 - (30%)
Similarity:	166/334 - (49%)	Gaps:	43/334 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 GSGSNNSGNSQ------------------TQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHS 369
            |.|..|:.|.:                  |:.:.:..:::..::     ||.|:.::.|....:.
Human   156 GKGMKNAMNMKDMKGGQLPQDDDDAETGLTEGEGEGEEEKEPEN-----LGKLQFSLDYDFQANQ 215

  Fly   370 LDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEP 434
            |...:::|.:|||:|..|.:|||.|: .:.|:...||    .||...||.||.||||..| .|..
Human   216 LTVGVLQAAELPALDMGGTSDPYVKV-FLLPDKKKKY----ETKVHRKTLNPAFNETFTF-KVPY 274

  Fly   435 EELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPN- 497
            :|||...:.:|::|.|::. ||.:|..||.::||.      :..|:   :::.:.....:..|.
Human   275 QELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVD------LGQPI---EEWRDLQGGEKEEPEK 330

  Fly   498 -GKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNP 561
             |.:..||.|......|.|.:.:..||..||..|.|||:|||.|..:..:.||.||:||.:||||
Human   331 LGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNP 395

  Fly   562 IYNEEFYFEASPHDLNKEMLILTVWDKD-LGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFH 625
            .:||.|.||.....:.|..:::||.|.| ||| |:.:|.:.:|:.:.|..|:.|.|.:..|....
Human   396 YFNESFSFEIPFEQIQKVQVVVTVLDYDKLGK-NEAIGKIFVGSNATGTELRHWSDMLANPRRPI 459

  Fly   626 EKWHCLAPD 634
            .:||.|.|:
Human   460 AQWHSLKPE 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	43/123 (35%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	50/132 (38%)
SYT2	XP_016855798.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910