DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and rph3aa

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_005172658.1	Gene:	rph3aa / 101886567	ZFINID:	ZDB-GENE-090706-2	Length:	598	Species:	Danio rerio

Alignment Length:	648	Identity:	210/648 - (32%)
Similarity:	326/648 - (50%)	Gaps:	117/648 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KTSEPLRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHAVERGPNCCRLCGDTFGILR 99
            :|.| |..||::.|.||:.|.:.:|..|::|:|||..|::.:|:.|...|.:.|.|||..||:..
Zfish     7 ETGE-LTDEEKQIINSVLERAKTMEAMEQERIGRLANRLDSMKRSACGDGYSRCLLCGQQFGLTG 70

  Fly   100 PQRILCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFFKGLPKYDMPR 164
            ...::|.:|::::||||.|      .:..||..||||:||.|.:||.|:||||||||.|:..:|.
Zfish    71 VSAVVCAECKKNMCTKCGV------QSVCRSGPIWLCKICCEHKEMLKQSGAWFFKGSPQQVLPA 129

  Fly   165 ----------SASATPIPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHSEP 219
                      |.|.|. .||....        ||...:.|:.|...::|.|....|:.:......
Zfish   130 PLAISNQRELSTSRTS-TNPSANQ--------QSPITSQTKNAESVQVTGREQQISAETMPAKRE 185

  Fly   220 EDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQ--- 281
            |                   :.:.|.|...||..|.|:  :::|  |......:.|....|:
Zfish   186 E-------------------RSVISQRALEEDGGRHRS--TVQS--DAAMEGQTFSPVVKREVPV 227

  Fly   282 QSQRP-----SECP-EYDSVSMSKLRRESSFLRRGSVSSSWSI-----------SDSSGSGSNNS 329
            ||.||     |..| :.|::|..:.|...:......:.::.|:           .|...:.|.:|
Zfish   228 QSSRPPASSFSTTPIQKDTMSRPEARAPPAMQADARLPAANSVPASRQPPPPTTEDEEDANSYDS 292

  Fly   330 GNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCK 394
            .::.|                   ||.||.::.|.|..:.|.|.:::|:.|..||:.||||||.|
Zfish   293 DDATT-------------------LGMLEFSLLYTEEKNELHCNIIKAKGLKPMDSNGLADPYVK 338

  Fly   395 LNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLG 458
            |::: |.| :|..: .||||:..|.||.:||||.:.|:..|::....:.:::.|:||:|| :|:|
Zfish   339 LHLL-PGA-SKSNK-LRTKTLRTTLNPVWNETLVYHGITNEDMQKKTLRLSVSDEDKFGHNEFIG 400

  Fly   459 AAKVCLS--TVHSTSQYRI------------------SVPLGVEDQYSNAAEMAQNWPNGKMLLS 503
            ..:|.|.  .::....|.:                  .:.|..|:...:.||     ..|::|:|
Zfish   401 ETRVVLKKLKLNQKKTYNVCLERVIPVRRTAGGGASRGMALYEEELKDDEAE-----ERGRILVS 460

  Fly   504 LCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFY 568
            |.||:::..|:|.|.:|.:|.|||:||.|||||||.||||..|..|:||.:|.:||||.:||||.
Zfish   461 LTYNSQQGRLIVGVVRCAHLAAMDSNGYSDPFVKICLKPDMGKKAKYKTQIKKKTLNPEFNEEFS 525

  Fly   569 FEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCL 631
            :|....:|.|:.|.::|||.|:||||||:|..|||..:|||.|:.|.:|::..|...|:||.|
Zfish   526 YEIKHGELAKKTLDVSVWDYDMGKSNDFIGGCQLGITAKGECLKHWYECLKNKDKKIERWHVL 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	39/97 (40%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	46/143 (32%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	67/131 (51%)
rph3aa	XP_005172658.1	PHD_SF	53..131	CDD:304600	36/83 (43%)
		C2A_Rabphilin_Doc2	298..421	CDD:176000	46/125 (37%)
		C2B_Rabphilin_Doc2	456..588	CDD:176030	67/131 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5199
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185575at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920