Protein Alignment Rph and sytl3

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_021324208.1
• Gene: sytl3 / 101882017
• ZFINID: ZDB-GENE-040724-150
• Length: 581
• Species: Danio rerio
• Alignment Length: 703
• Identity: 146/703 - (20%)
• Similarity: 247/703 - (35%)
• Gaps: 211/703 - (30%)

  Fly     1 MDFQNRNNTANKFVCPSDRQLALRAKLKAGWSSSKTSEPLRPEEQEAIISVIRRNEEIEVAERQR 65
            ::.:|..:..|.| ||.|  |.|...|                |:|.::.|::|::.:...:..|
Zfish     3 LEQKNWEDRKNDF-CPLD--LGLFQAL----------------ERERVLEVLQRDKALRTIDADR 48

  Fly    66 VGRLVERVEKIKQHAVERGPNC---CRLCGDTFG---ILRPQRIL---------CEDCRQSVCTK 115
            |.||     :::.|.:     |   .|:....||   ..|.||:|         |..|...:|.:
Zfish    49 VRRL-----RVELHGL-----CLQTSRIISRPFGQRSCARCQRVLGKFWDCGSVCCGCSHRICNR 103

  Fly   116 CSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFF-------------------KGLPKYD 161
            |.|         .||...|.|.:|...||...|||.||.                   |.|..|.
Zfish   104 CQV---------VRSAHDWKCTVCHAYREFKIKSGEWFLEQQAKKFPSVKENSETTGDKMLQSYQ 159

  Fly   162 -MPRSASATPIPNP--GPGSM-------AGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGH 216
             :...|...|.|.|  .|.|.       ...|:::::..|:.:  |.:|||:...||.|..:.
Zfish   160 RLSFIAVVPPTPPPFYNPPSFNRLEEHKKPFTKSMENLVASVS--AHIKKLSKSQNDLSEVAG-- 220

  Fly   217 SEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQ 281
               :..||.|                            ...|...:|..||.         .||.
Zfish   221 ---QLTVDHG----------------------------HMMYSRRKSLSDGA---------INRA 245

  Fly   282 QSQRPSECP---EYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQ 343
            ..:.|| .|   ...|.|.|.|     .|....|||:.:.||.....::::|
Zfish   246 LCKVPS-LPILSTAQSTSTSTL-----CLTDDDVSSTSAYSDDQRDSNSSTG------------- 291

  Fly   344 QLQQHCRDPLL--------GWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITP 400
                  .|.:|        |.:|:.::|......|:.|:...|:|...|......||..:.::..
Zfish   292 ------MDSVLFENTISVTGEIEVVLAYNNRTSCLEITIKACRNLMFRDTKKKCHPYVNVCLLPK 350

  Fly   401 EAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGHD-------FLG 458
            :.|    .::....|.|.:||.:|||...| :..:.|.::::.::::      |.       |||
Zfish   351 KCH----NFKMKTAVRKGKNPVYNETFTCV-LSADLLSSAVLQLSVW------HSRGLKRRLFLG 404

  Fly   459 AAKVCLSTV---HSTSQYRISVPLGVE-DQYSNAAEMAQNWPNGKMLLSLCY------NTKRRAL 513
            ...:.|:.:   .:.||..:...|..: .|....||:  .:.:..:|:...:      ||:...:
Zfish   405 ETLIRLADMDLEDTDSQRSLCCKLNPKAPQLGGDAEL--QFTSVLLLIQAQFHTLPHNNTQTHGV 467

  Fly   514 VVNVKQCINLMAMD-----NNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASP 573
            ::.....:.::..|     :...:..|..|...| .|:....|||...:|...|  ...:...|.
Zfish   468 LLGAPGQLTVLFTDVSKLLSVSKTAHFEGILCLP-GHRELVRKTSALKKTDGSI--RMSFSSLSQ 529

  Fly   574 HDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHE 626
            .:|.:..|.|.:|:|     |..|.|.:|..:|..:.||      |:|..:.|
Zfish   530 QELQQATLTLNLWEK-----NCLLTSARLHKESSWQHLQ------RMPGVWQE 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	30/122 (25%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	28/140 (20%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	29/139 (21%)
sytl3	XP_021324208.1	PHD_SF	27..134	CDD:473978	34/125 (27%)
		FYVE_like_SF	73..120	CDD:333710	14/55 (25%)
		C2	304..429	CDD:472691	27/135 (20%)