DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and doc2a

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_031748920.1	Gene:	doc2a / 101730387	XenbaseID:	XB-GENE-922476	Length:	391	Species:	Xenopus tropicalis

Alignment Length:	332	Identity:	123/332 - (37%)
Similarity:	179/332 - (53%)	Gaps:	31/332 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 GSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLA 389
            |:..:.:|.....|...:        ...||.||..:.|......|.|.::||:.|..||..|||
Frog    65 GAETADDSADVDNYDSDE--------STALGTLEFDLLYDPEQCILQCCILRAKGLKPMDFNGLA 121

  Fly   390 DPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH 454
            |||.|:::: |.| .|..: .:|:||..:.||.:||:|.:.|:..|::|..::.:::.|:||..|
Frog   122 DPYVKIHLL-PGA-CKANK-LKTRTVRNSLNPTWNESLTYCGITQEDMGKKILRISVCDEDKLSH 183

  Fly   455 -DFLGAAKVCLSTV------HSTSQYRISVPLGVEDQ----------YSNAAEMAQNW---PNGK 499
             :|:|..:|.|..:      |........:||.....          |....|..|.|   ..|:
Frog   184 NEFIGETRVPLRRLKPGERKHFNLCLERQIPLASPSSMTAALRGISCYLKELERCQEWELEERGR 248

  Fly   500 MLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYN 564
            :||||.|:::|..|||.:.:|.:|.|||.||.|||:||..||||..|..||||.||.:||||.:|
Frog   249 ILLSLTYSSERGGLVVGIMRCAHLAAMDVNGFSDPYVKTYLKPDVEKKSKHKTVVKKKTLNPEFN 313

  Fly   565 EEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWH 629
            |||::..|..:|.|..|.:||||.||||||||:|.:..|..||||.|:.|::|:..|:...|.||
Frog   314 EEFFYNISQLELQKRSLEVTVWDYDLGKSNDFIGGVTFGMSSKGECLKHWMECLSTPNKRTEHWH 378

  Fly   630 CLAPDNP 636
            .|..:.|
Frog   379 TLTNELP 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	42/129 (33%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	69/131 (53%)
doc2a	XP_031748920.1	C2A_Rabphilin_Doc2	86..209	CDD:176000	42/125 (34%)
doc2a	XP_031748920.1	C2	248..380	CDD:417471	69/131 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5333
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185575at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm47802
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010