DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and syt15

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_002941809.1	Gene:	syt15 / 100496499	XenbaseID:	XB-GENE-6050096	Length:	420	Species:	Xenopus tropicalis

Alignment Length:	356	Identity:	82/356 - (23%)
Similarity:	143/356 - (40%)	Gaps:	42/356 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 QQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQL 345
            |....|...|:              ||.|   ||..|:..:...||.|      .:.|:..::..
Frog    98 QDDSEPYTAPD--------------FLPR---SSFCSLGGAYVVGSIN------PALYKFPEENE 139

  Fly   346 QQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQ 410
            :....:..:|.:..|:.|......|..::::.|:|  ...:...:|:.|::::..|     .|..
Frog   140 ETDFPEGNIGRIWFAVEYELETERLVVSLMKVRNL--QFGSDSCNPFVKIHLLPDE-----RRHL 197

  Fly   411 RTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKY-GHDFLGAAKVCLSTVHSTSQYR 474
            ::||..||.||:|:||..| .|..:.:....:..:::..||. .|..||.....|.....|....
Frog   198 QSKTKRKTVNPQFDETFVF-QVSGKTVHQRTLRFSIYHVDKIKKHHLLGQVVFPLKNESLTDDEN 261

  Fly   475 ISVPLGVE-DQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNG-SSDPFVK 537
            :.:...:| :.....:|.      |.:..||.||.....|.|.:.:...|..::..| .|..|||
Frog   262 VVIWRDLELENLEPPSEY------GNIQFSLSYNDYLGRLTVVLLRAKGLQFLEERGVISSAFVK 320

  Fly   538 IQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQL 602
            :.........|..||:....|.||:|||.|.|:.....|:...|.|.|:....|:.:..||.:.:
Frog   321 VSFMNHNKLVKCKKTAAICGTANPVYNETFSFKVEHIGLDTASLSLAVYQNAQGEKSHLLGRVVV 385

  Fly   603 G--AQSKGERLQQWLDCIRLPDHFHEKWHCL 631
            |  ..::|..|:.|.:.:..|....::||.|
Frog   386 GPYMYTRGRELEHWNEMLNKPKDLVKRWHAL 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	28/123 (23%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	37/134 (28%)
syt15	XP_002941809.1	TM_EGFR-like	7..32	CDD:213052
		C2A_Synaptotagmin-15-17	149..269	CDD:176036	28/127 (22%)
		C2B_Synaptotagmin-15	279..417	CDD:176054	39/144 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910