DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and doc2b

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_002934390.1	Gene:	doc2b / 100496262	XenbaseID:	XB-GENE-6032690	Length:	394	Species:	Xenopus tropicalis

Alignment Length:	370	Identity:	130/370 - (35%)
Similarity:	205/370 - (55%)	Gaps:	37/370 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 SNSFFFN-RQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQS 336
            :||...| .|.|..|.|..:.:...:.||     |...|:.|::.:..:..|.......:..|
Frog    50 ANSLKSNVSQPSVSPCETSKEEEEDVDKL-----FGAYGAASTAPAKHEEEGDLDGYDSDDCT-- 107

  Fly   337 QYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPE 401
                            .||.|:.::.|.:..::|.||:.:|:.|..||..||:|||.||::: |.
Frog   108 ----------------TLGTLDFSLLYDQENNALHCTINKAKGLKPMDHNGLSDPYVKLHLL-PG 155

  Fly   402 AHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLGAAKVCLS 465
            | :|..: .||||:..|.||.:||||.:.|:..|::....:.:::.|:||:.| :|:|..::.|.
Frog   156 A-SKANK-LRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRIPLK 218

  Fly   466 TV--HSTSQYRISV--PLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAM 526
            .:  :.|..:.|.:  .|.::.....:.|     ..|::|:||.|::::..|:|.:.:|.:|.||
Frog   219 KLKPNQTKNFSICLEKQLPIDKTEDKSLE-----ERGRILISLKYSSQKSGLLVGIIRCAHLAAM 278

  Fly   527 DNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLG 591
            |.||.|||:||..||||..|..||||:||.:||||.:||||.:|....||.|:.|.:||||.|:|
Frog   279 DANGYSDPYVKTYLKPDEDKKSKHKTAVKKKTLNPEFNEEFCYEIKHSDLAKKTLEVTVWDYDIG 343

  Fly   592 KSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCLAPDNP 636
            |||||:|.:.||..:|||||:.|.||::..|...|:||.|..:.|
Frog   344 KSNDFIGGVVLGINAKGERLKHWFDCLKNKDKKIERWHTLTNELP 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	43/125 (34%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	68/131 (52%)
doc2b	XP_002934390.1	C2A_Rabphilin_Doc2	109..232	CDD:176000	43/125 (34%)
doc2b	XP_002934390.1	C2B_Rabphilin_Doc2	251..383	CDD:176030	68/131 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5333
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185575at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm47802
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010