Protein Alignment Rph and sytl5

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_012813070.1
• Gene: sytl5 / 100496000
• XenbaseID: XB-GENE-982310
• Length: 814
• Species: Xenopus tropicalis
• Alignment Length: 822
• Identity: 184/822 - (22%)
• Similarity: 299/822 - (36%)
• Gaps: 251/822 - (30%)

  Fly    33 SSKTS----EPLRPEEQEAIISVIRRNEEIEVAERQRVGRL------VERVEKIKQHAVERGPNC 87
            ||||.    ..|..:|:::|::|:.|::.::..:.:||.||      ::|....:.|..::....
 Frog     2 SSKTEIINFSFLSEQEKKSILTVLERDDLLKKTDGKRVRRLKNELLEIQRRGNKRHHVRQQNSKI 66

  Fly    88 CRLCGDTFGILRPQRILCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAW 152
            |..|..:.|::..:..||..|.|.||..|.|.:         ....|.|.:|::..::...:|.|
 Frog    67 CARCRKSLGLIFDRGDLCHVCHQRVCKACRVVV---------KDGKWKCTVCAKIAQLKLTTGDW 122

  Fly   153 F-------FK---------------------GLPKYDMPRSASATPI-PNPGPGSM-------AG 181
            |       ||                     ..|..|:..|....|. .|...||:       ..
 Frog   123 FCEERGKRFKNGTVLGSDIVRKSIMRKIPAVSKPDRDVEDSGKQLPANENVQNGSVLENKSAKGE 187

  Fly   182 DTRAV------QSCHATPTRPA--RVKKL--------------------------TIRVN-DSSS 211
            |.|::      ||.|:..:.|.  |:..|                          .::|| .|.|
 Frog   188 DGRSIRSDIDNQSLHSNRSMPRSDRISNLFDKMTGKKAKNEEDDAQSLRSMRSDRKVKVNVHSES 252

  Fly   212 SSSGHSEPE------------------------------DEVDTGVGIGVGVVGGGMAKGIASTR 246
            ..:..:|.|                              |.:|||       |....:||.|.:.
 Frog   253 LQAAVTEQENTDMISQASFKVDVRSESRPGSSLSARGSVDSLDTG-------VSSPKSKGNAPSS 310

  Fly   247 LQREDSFRLRAYGSI--------------------RSFIDGGERKLSN-----SFFFNRQQSQRP 286
            .|   |..:...|::                    ||.:..|.:..|:     |....|:.|..|
 Frog   311 YQ---SSSINVIGTLPARQSSPTASMHSAASNSHSRSGVQNGTKTSSSIPEDMSKGHERRASATP 372

  Fly   287 S------------ECPEYD-SVSMSKLRRESSFLRRGSVSSSWSIS-----------DSSGSGSN 327
            |            ...||| |...::..:||..:|..||....:..           |..|..:|
 Frog   373 SLVISRASLSSEQSKSEYDLSGHFTEENQESISMRSISVPDYLNKDPEYIDKIDEDFDDLGPSTN 437

  Fly   328 --NSGNSQTQSQYQQHQQQLQQHCRDP-------------------LLGWLEIAISYREAFHSLD 371
              .|.|:.|.|..:.....:.....|.                   :.|.:.:.|:|.....:|:
 Frog   438 LTKSMNAHTLSDRKWTHLNVPDADADTRSLTSISLYSETGDYGNLRITGEILLNINYSYKTGALN 502

  Fly   372 CTMVRARDLPAMD-AAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPE 435
            ..:...|:|...| .....|||.|..:: |:...:..|  :||....|.:|:|||||::| :...
 Frog   503 VVVKNCRNLAVADEKKNRTDPYVKAYLL-PDKSRQSKR--KTKIKTNTTDPDFNETLKYV-ISHT 563

  Fly   436 ELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVH--------------------STSQYRISVPL 479
            :|....:.:.::.:|::| :.|||...:.|.:.:                    .|.||:..:.:
 Frog   564 QLETRTLQLTVWHNDRFGRNSFLGEVDIPLDSCNFENQEDECFQLQPKMDLASDVTLQYKGEITV 628

  Fly   480 GVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALV---------VNVKQCINLMAMDNNGSSDPF 535
            |:  :|. ..|.....|..|:.....:...::|.|         |.:|...||.||.:.||||.|
 Frog   629 GL--RYI-TPEKNLTLPLDKVAEKKSFRKSKKANVKVPSGGLVEVLIKNAKNLTAMKSGGSSDTF 690

  Fly   536 VKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEA-SPHDLNKEMLILTVWDKDLGKSNDFLGS 599
            ||..|.||.:|:.||||.|..:|:||.:|..|.|.: ...||:...:.||||.|:...||.|||.
 Frog   691 VKGYLLPDNNKSTKHKTPVVKKTVNPEWNHTFTFASLQTSDLSNVCVELTVWGKESLTSNVFLGG 755

  Fly   600 LQLG---AQSKGERLQQWLDCIRLPDHFHEK--WHCLAPDNP 636
            :.||   ..|.|: :..|:|     .|..|:  |..:. |||
 Frog   756 VCLGCGSGVSYGD-IVDWMD-----SHGEEQFLWQKMM-DNP 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	23/116 (20%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	33/144 (23%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	52/146 (36%)
sytl5	XP_012813070.1	PHD_SF	11..123	CDD:473978	26/120 (22%)
		FYVE_Slp5	65..111	CDD:277305	14/54 (26%)
		C2A_SLP-4_5	485..609	CDD:175995	30/127 (24%)
		C2B_SLP_1-2-3-4	623..801	CDD:175987	59/178 (33%)