DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and syt5

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_002938321.1	Gene:	syt5 / 100493612	XenbaseID:	XB-GENE-991349	Length:	416	Species:	Xenopus tropicalis

Alignment Length:	286	Identity:	100/286 - (34%)
Similarity:	147/286 - (51%)	Gaps:	22/286 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 LGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKT 418
            ||.|:.::.|......|...:::|.||||:|..|.:|||.|:.:: |:...||    .||...||
Frog   136 LGKLQYSLDYDFQTGQLVVGIIQAADLPALDIGGTSDPYVKVYLL-PDKKKKY----ETKVHRKT 195

  Fly   419 RNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTV---HSTSQYRISVPL 479
            .||.|||:..| .|...|||...:.::::|.|::. ||.:|..:|.::||   |...::
Frog   196 LNPTFNESFTF-KVPYAELGGKTLVMSVYDFDRFSKHDAIGEVRVHMNTVDLAHVIEEW------ 253

  Fly   480 GVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDA 544
                |...:||..:....|.:..||.|......|.|.|.:..||..||..|.|||:|||.|..:.
Frog   254 ----QDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKIHLMQNG 314

  Fly   545 HKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKD-LGKSNDFLGSLQLGAQSKG 608
            .:.||.||::|..||||.|||.|.||.....:.|..::|||.|.| ||| |:.:|.:.:|..:.|
Frog   315 KRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVLTVLDYDKLGK-NEAIGKIFVGCNATG 378

  Fly   609 ERLQQWLDCIRLPDHFHEKWHCLAPD 634
            ..|:.|.|.:..|.....:||.|.|:
Frog   379 TELRHWSDMLANPRRPIAQWHTLQPE 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	42/126 (33%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	52/132 (39%)
syt5	XP_002938321.1	C2A_Synaptotagmin-1-5-6-9-10	135..258	CDD:176031	43/137 (31%)
syt5	XP_002938321.1	C2B_Synaptotagmin-1	267..402	CDD:176047	53/135 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000