DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and syt7b

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_001232886.1	Gene:	syt7b / 100334336	ZFINID:	ZDB-GENE-090601-6	Length:	488	Species:	Danio rerio

Alignment Length:	366	Identity:	100/366 - (27%)
Similarity:	170/366 - (46%)	Gaps:	57/366 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 QQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQL 345
            ::|.:|...|:..:...|..|.:::.          |:||.:.|.:::.......|:.::|:..:
Zfish   163 KRSNKPGSSPKGQTPDESHRRTDANS----------SVSDLANSVTSDMLMLSPGSEEEEHEGPV 217

  Fly   346 QQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQ 410
               |..  ||.::.::.|.....:|...:::.:||||.|.:|.:||:.||.::..:.|.     .
Zfish   218 ---CEK--LGRIQFSVGYSFQDSTLTVKILKGQDLPAKDFSGTSDPFVKLYLLPDKKHK-----L 272

  Fly   411 RTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYR 474
            .||...|..||.:|||..|.|...|::....:|:.:.|.|::. :|.:|               .
Zfish   273 ETKVKRKNLNPHWNETFLFEGFPYEKVVQRTLYLQVLDYDRFSRNDPIG---------------E 322

  Fly   475 ISVPLGVEDQYSNAAE---MAQNW-----------PNGKMLLSLCYNTKRRALVVNVKQCINLMA 525
            :|:||       |..|   |...|           ..|.:|:|||||.....:.|::.:..||.|
Zfish   323 VSIPL-------NKVELVPMQTLWKELKPCSDGSGSRGDLLVSLCYNPTANIITVSIIKARNLKA 380

  Fly   526 MDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDL 590
            ||..|:|||:||:.|.....:.:|.||.|..|.|||::||.|.|:...|.|.:..:::||.|||.
Zfish   381 MDIGGTSDPYVKVWLMNKDKRVEKKKTVVMKRCLNPVFNESFPFDVPAHVLRETTIVITVMDKDR 445

  Fly   591 GKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCL 631
            ...||.:|.:.|..:|....::.|.|.:..|.....:||.|
Zfish   446 LSRNDVIGKIYLSWKSGPAEVKHWKDMMSHPRTAVAQWHAL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	31/123 (25%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	48/131 (37%)
syt7b	NP_001232886.1	C2A_Synaptotagmin-7	220..344	CDD:176032	38/152 (25%)
syt7b	NP_001232886.1	C2B_Synaptotagmin-7	352..487	CDD:176050	50/135 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910