Protein Alignment Rph and syt6a

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_017209198.1
• Gene: syt6a / 100149310
• ZFINID: ZDB-GENE-090601-2
• Length: 537
• Species: Danio rerio
• Alignment Length: 551
• Identity: 133/551 - (24%)
• Similarity: 221/551 - (40%)
• Gaps: 141/551 - (25%)

  Fly   134 W-LCRICSETREMWKKSGAWFFKGLPKYDMPRSASATPIPNPGP-------------GSMAGDTR 184
            | ||.|....:.:...|.|     |...|.|.....:.:|:|.|             .||.....
Zfish    79 WKLCWIPWRNKALSSSSAA-----LAPDDCPSPHIPSVLPSPQPSEAMATEKEKYPMASMGFLEA 138

  Fly   185 AVQSCHATPTRPARVKKLTIR---VNDSSSSSSGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTR 246
            ||:..|.:|..||.| :|::|   :..:.......:||                      .:||
Zfish   139 AVKISHTSPDIPAEV-QLSMREHFLRRTQRMQRQTTEP----------------------ASST- 179

  Fly   247 LQREDSFRLRAYGSIR-SFIDGGERKLSNSFFFNRQQSQRPSECPEYD----SVSMSKLRRESSF 306
              |..||:......:: |.:|.|:                     :||    ..|:.:::.|  .
Zfish   180 --RHSSFKRHLPRQMQVSSLDLGD---------------------DYDVDEQPTSIGRIKPE--L 219

  Fly   307 LRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLD 371
            .::.:..:..|   ::..|..|.|......:|....:.|.
Zfish   220 YKQMTTENDES---ANSKGGKNCGKINFSLRYDYENEMLL------------------------- 256

  Fly   372 CTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEE 436
            ..:::|.||||.|..|.:|||.|:.:: |:...|:    :|:...||.||.|:|:.|| .|..:|
Zfish   257 VKILKAFDLPAKDLCGSSDPYVKIYLL-PDRKQKF----QTRVHRKTLNPTFDESFQF-PVPYDE 315

  Fly   437 LGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKM 500
            |....:::::||.|::. ||.:|  :|.|..:...|.......:..:.||:.    :::...|::
Zfish   316 LAVRKLHLSVFDFDRFSRHDMIG--EVILDNLFEVSDLSRETSIWRDIQYAT----SESVDLGEI 374

  Fly   501 LLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNE 565
            :.||||......|.:.|.:|.||.|||..|.|||:||:.|..|..:.||.||:.|..||||.|||
Zfish   375 MFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLICDGRRLKKKKTTTKKNTLNPTYNE 439

  Fly   566 EFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLP----DHFH- 625
            ...|:..|..:::..|.::|.|.||...|:.:|..:||..::|.....|.:.:..|    .|:|
Zfish   440 AIIFDIPPESMDQVSLHISVMDYDLVGHNEIIGVCRLGCGAEGLGRDHWNEMLAYPRKPIAHWHP 504

  Fly   626 --------EKW-----------HCLAPDNPA 637
                    ::|           .|.:|..||
Zfish   505 LLESKKTEKEWKARTASFDSQGSCPSPKPPA 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	9/38 (24%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	34/123 (28%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	49/155 (32%)
syt6a	XP_017209198.1	C2A_Synaptotagmin-1-5-6-9-10	238..363	CDD:176031	38/157 (24%)
		C2B_Synaptotagmin-3-5-6-9-10	372..505	CDD:176048	49/132 (37%)