Protein Alignment Rph and pcloa

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_073803181.1
• Gene: pcloa / 100148002
• ZFINID: ZDB-GENE-030131-8115
• Length: 4953
• Species: Danio rerio
• Alignment Length: 733
• Identity: 147/733 - (20%)
• Similarity: 248/733 - (33%)
• Gaps: 222/733 - (30%)

  Fly     1 MDFQNRNNTAN--KFVCPSDRQLALRAKLKAGWSSSKTSEPLRPEE----QEAIISVIRRNEEIE 59
            |.:|...||:|  |:....|.:     .|:..:||...|....|..    |:.|...:|:|
Zfish  3936 MLYQKHKNTSNIGKYSSMQDSR-----GLETDYSSYLGSSSSSPRSSRLMQDEITFGLRKN---- 3991

  Fly    60 VAERQRVGRLVERVEKIKQHAVERGPNCCRLCGDTFGI-LRPQRILCEDCRQSVCTKCSVDINIR 123
            :||:|                        :..|.|.|. |.....|.:....|...:.|:..:..
Zfish  3992 IAEQQ------------------------KYLGSTLGANLAGSLNLGQSLNLSPGMRSSLGEDSS 4032

  Fly   124 YHTSERSREIWLCRICSETREMWKKSGAWFFKGLPKYDMPRSASATPIPNPGPGSMAGDTRAVQS 188
            |.:..|||.      .|....::         || ...:.|..|::.:.....|..:.:|.|.|
Zfish  4033 YPSGSRSRP------SSRPSSVY---------GL-DLSIKRDLSSSSLRLKAEGEASSETSAFQ- 4080

  Fly   189 CHATPTRPARVKKLTIRVNDSS-------SSSSGHSEPEDEVDTGVGIGVGVVGG---------- 236
               ||:  .|.|..::.:..|.       :.:|....|...|...:|:.....|.
Zfish  4081 ---TPS--GRSKPTSLPIVQSGRGRIPIVAQNSEEESPLSPVGQPMGMARASAGPLPPISADSRD 4140

  Fly   237 --GMAKGIASTRLQ--REDSFRLRAY---------------------GSIRSFIDGGERKLSNSF 276
              |....:..::.|  |||..|.|.|                     |..|.........::|::
Zfish  4141 QFGSCMSLQESQQQHLREDPSRGRGYVLMDDLQGTMSDSEALSESLVGLSRDDPGNSHENVTNAY 4205

  Fly   277 FFNRQQS---QRPSECPEYDSVSMSKLRRESSF----------LRRGSVSSSWS--------ISD 320
            ...|:::   .:|.:....:...|.  ||:..|          |.|.....|.|        :..
Zfish  4206 HLRREETDWFDKPRDGRAENGQGME--RRQGKFHYPFPHARIKLLRDPKDRSVSGNGLGIRVVGG 4268

  Fly   321 SSGSGSNN-----------SGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAIS---YREAFHSLD 371
            ....|||.           .|.::...:..:..|.|:         |..|::|   |.|....:.
Zfish  4269 KEVPGSNGDIGAYVAKVLPGGAAEQTGKIVEGMQVLE---------WNNISLSGKTYEEVQGLVG 4324

  Fly   372 CTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEE 436
            ..:..|.....:|          :|:::....:......:.|.....|:|         ||:|::
Zfish  4325 HQVGEAELCIRLD----------INMLSDSDSSHLDLHDQVKGDRPPRSP---------GVDPKQ 4370

  Fly   437 LGNSLIYVALFDDDKYGHDFLGAAKVCLSTVHSTSQYRISVPLG------------------VED 483
            |...|                  .||....|.|:|...:..|..                  .:.
Zfish  4371 LAAEL------------------QKVSQQQVPSSSASALDKPSASAGSSAVPSPGQPGSPSVSKK 4417

  Fly   484 QYSNAAE--MAQNWP-NGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPD-- 543
            ::|..:|  ..|:.| :|::.|.:.|:.:...|:|:|.|..||...||||.||||||:.|.|.
Zfish  4418 RHSKNSEGTKTQSHPVSGEIQLQINYDKQLGNLIVHVLQARNLAPRDNNGYSDPFVKVYLLPGRG 4482

  Fly   544 --------AHKNKKHKTSVKWRTLNPIYNEE-FYFEASPHDLNKEMLILTVWDKDLGKSNDFLGS 599
                    :.:||:....|: :||||.:|:. .|.......|.|:.|.::|||.|...:|||||.
Zfish  4483 QVMVVQNASAENKRRSKHVQ-KTLNPEWNQTVIYKNIHLEQLRKKTLEVSVWDYDKSSANDFLGE 4546

  Fly   600 --LQLGAQSKGERLQQWL 615
              :.|...::.:.:.:||
Zfish  4547 VLIDLSNTAQLDNVPRWL 4564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	16/88 (18%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	21/125 (17%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	44/130 (34%)
pcloa	XP_073803181.1	None