Protein Alignment Rph and doc2b

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_017211854.1
• Gene: doc2b / 100006713
• ZFINID: ZDB-GENE-090615-1
• Length: 648
• Species: Danio rerio
• Alignment Length: 684
• Identity: 224/684 - (32%)
• Similarity: 348/684 - (50%)
• Gaps: 112/684 - (16%)

  Fly    12 KFVCPSDRQLALRAKLKAGWS-------SSKTSEPLRPEEQEAIISVIRRNEEIEVAERQRVGRL 69
            ::|||:||||.|||||..|||       ..:.::.|...|.:.|:|||.|.|::|:.|:.|:|||
Zfish    12 QWVCPNDRQLMLRAKLHTGWSIHTFQSERQRKAQALEKRELDLIMSVIHRAEQLELIEQHRIGRL 76

  Fly    70 VERVEKIKQHAVERGPNCCRLCGDTFGILRPQRILCEDCRQSVCTKCSVDINIRYHTSERSREIW 134
            |||::.::..|:..|.:.|.|||:.||:|....:||.||...|||||.::..    ...:.|..|
Zfish    77 VERLDNMRSSAMGNGLSQCLLCGEVFGLLGSSSVLCLDCCMKVCTKCGIETT----AGGQKRTQW 137

  Fly   135 LCRICSETREMWKKSGAWFFKGLPKYDMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRPARV 199
            ||:||||.||:||:|||||:|.|||:..|...|.  :.|..|....|:...|       .|.|.:
Zfish   138 LCKICSEQREVWKRSGAWFYKALPKHIRPIKDSI--LDNRKPVIERGEQLPV-------ARSAPI 193

  Fly   200 K----KLTIRVNDSSSSSSGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGS 260
            .    :..:.:::|..|.:..||...:                .|..||...||.||..
Zfish   194 SYTWAQSRVYLSESDGSDAELSECSSD----------------RKTFASETNQRRDSES------ 236

  Fly   261 IRSFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSF------------------- 306
                 .||:.:...|.|.:..:.....|.|   |..:|:....|||
Zfish   237 -----SGGQVQTPQSSFTSPTRGNVHIESP---SSLVSEQSSSSSFNPGLEDEVIDHSRTLLTPP 293

  Fly   307 --LRRGSVSSSWSISDSSGSGSNNS----------GNSQTQSQYQQHQQQLQQHCRD--PLLGWL 357
              .|.||:.||.:...|.|..::.:          |.:...:..::.:..::.:..|  ..||.|
Zfish   294 ALSRAGSLRSSSTSQKSEGPQADANRDEDDLDQAFGATALVASKKEEEPDVEGYDSDDSTTLGTL 358

  Fly   358 EIAISYREAFHSLDCTMVRA--------RDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKT 414
            :.::.|.:..::|.||:.:|        :.|..||..||:|||.||::: |.| :|..: .||||
Zfish   359 DFSLLYDQENNALHCTINKAKLPVPRYKKGLKPMDHNGLSDPYVKLHLL-PGA-SKANK-LRTKT 420

  Fly   415 VHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLGAAKVCLSTVHSTSQYRIS-- 476
            :..|.||.::|||.:.|:..|::....:.:::.|:||:.| :|:|..::.|..:........|
Zfish   421 LRNTLNPVWSETLTYYGITDEDMVRKTLRISVCDEDKFRHNEFIGETRIPLKKLKPNQTKNFSNC 485

  Fly   477 ----VPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVK 537
                :|:...|..|..       ..|::::||.|::::..|||.:.:|.:|.|||.||.|||:||
Zfish   486 LEKQLPIDKTDDKSLE-------ERGRIMISLKYSSQKSGLVVGIIRCAHLAAMDANGFSDPYVK 543

  Fly   538 IQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQL 602
            ..||||.:|..||||:||.:||||.:||||::|....||:|:.|.:||||.|:||||||:|.:.|
Zfish   544 TYLKPDENKKSKHKTAVKKKTLNPEFNEEFFYEIKYADLSKKTLEVTVWDYDIGKSNDFIGGVSL 608

  Fly   603 GAQSKGERLQQWLDCIRLPDHFHEKWHCLAPDNP 636
            |..:.||||:.|.||::..|...|:||.|..:.|
Zfish   609 GINASGERLKHWFDCLKNKDKKIERWHTLTNELP 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	40/87 (46%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	41/137 (30%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	67/131 (51%)
doc2b	XP_017211854.1	PHD_SF	51..158	CDD:473978	51/110 (46%)
		C2A_Rabphilin_Doc2	355..486	CDD:176000	41/133 (31%)
		C2B_Rabphilin_Doc2	505..637	CDD:176030	67/131 (51%)