DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and doc2d

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_001122026.1	Gene:	doc2d / 100002795	ZFINID:	ZDB-GENE-081104-451	Length:	429	Species:	Danio rerio

Alignment Length:	332	Identity:	122/332 - (36%)
Similarity:	193/332 - (58%)	Gaps:	18/332 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 ISDSSGSGSNNSGNSQTQSQYQQHQQQL-QQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLP 381
            :.|....|..:....:.:.:.|:...:. .....|..||.||..:.:.:..:.|.||:.:|:.|.
Zfish   101 LKDKDKDGDRDGEKDRKREREQEENGEFADSDDDDTYLGTLEFNLLFDQENNCLHCTIHKAKGLK 165

  Fly   382 AMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVAL 446
            |||:.||||||.||::: |.| :|..: .||||:..|.||.:||||.:.|:...::....:.:.:
Zfish   166 AMDSNGLADPYVKLHLL-PGA-SKANK-LRTKTLKNTLNPVWNETLIYHGITAADMTTKTLRLCV 227

  Fly   447 FDDDKYG-HDFLGAAKVCLSTVH--STSQYRISVPLGVEDQYSNAAEMAQNWP-----NGKMLLS 503
            .|.|:.| ::|:|..:|.|..:.  .:.:|.:.:....:.:..|:..|....|     .|::|:|
Zfish   228 CDMDRLGRNEFIGEVRVALKKLKEGESKKYNMGLERIAQTREGNSQAMDPAAPVAEEERGRILVS 292

  Fly   504 LCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFY 568
            |.|||::..|||.:.:|.:|.|||:||.|||||||.|:||..|..|:||:||.:||||.:||||.
Zfish   293 LLYNTEKNTLVVGIIRCAHLAAMDSNGYSDPFVKIILQPDMGKKSKYKTTVKKKTLNPEFNEEFS 357

  Fly   569 FEASPHD-LNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCL- 631
            ::. ||| |.|:.|.::|||.|||.||||:|.::||..:||:||:.|.:|::......|.||.|
Zfish   358 YDV-PHDQLAKKTLEISVWDYDLGMSNDFIGGVELGINAKGDRLKHWFECLKYKGKKVEYWHTLT 421

  Fly   632 ---APDN 635
               ||.:
Zfish   422 QQGAPSS 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	43/125 (34%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	68/132 (52%)
doc2d	NP_001122026.1	C2A_Rabphilin_Doc2	138..261	CDD:176000	43/125 (34%)
doc2d	NP_001122026.1	C2B_Rabphilin_Doc2	288..420	CDD:176030	68/132 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5199
eggNOG	1	0.900	-	-		E1_KOG1013
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185575at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm24915
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45729
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.880