DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and syt3

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_005164031.1	Gene:	syt3 / 100000615	ZFINID:	ZDB-GENE-090601-1	Length:	566	Species:	Danio rerio

Alignment Length:	469	Identity:	124/469 - (26%)
Similarity:	192/469 - (40%)	Gaps:	92/469 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 GIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFN-RQQSQR------ 285
            |.|:|.||||....:....|||:|:..                  |:|.:.. .||.|.
Zfish   101 GAGLGGVGGGGGASLLPPLLQRKDTHS------------------SSSLYPTLSQQGQHHPHFSD 147

  Fly   286 ------------------PSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNS 332
                              |.|..|:..:.|......::.|:....|.....:...||.:.:..|:
Zfish   148 VMGVEGGGGLVVGGVVGGPQEMQEHSYLDMDSYPNNAATLKLSQTSPELPPATEGGSAAKDLPNA 212

  Fly   333 QTQSQYQQHQQQLQQHCRDP------------LLGWL----------------------EIAISY 363
            .:|.|.....:.:......|            .:|.:                      :|:...
Zfish   213 HSQQQVTTRPKPMTHQLSSPDFHGEEKSEQLTSIGQIKPELYRLRQGDQGDGKQGNNCGKISFLL 277

  Fly   364 REAFHS--LDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNET 426
            |.||::  |...:::|.||||.||.|.:|||.|:.:: |:...|:    :||...||.||.||||
Zfish   278 RYAFNTEQLVVKILKALDLPAKDANGFSDPYVKIYLL-PDRKKKF----QTKVHRKTLNPVFNET 337

  Fly   427 LQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAE 490
            .|| ||...||....::.:::|.|::. ||.:|  :|.:..:...|:.....|:. .|.....||
Zfish   338 FQF-GVPLAELHARKLHFSVYDFDRFSRHDLIG--QVVVDNLLDFSEGTGEKPIW-RDIVEGTAE 398

  Fly   491 MAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVK 555
            .|.   .|::..||||......|.|.:.:..||.|||..|.|||:||..|..:..:.||.|||:|
Zfish   399 KAD---LGELNFSLCYLPTAGRLTVTIIKATNLKAMDLTGFSDPYVKASLVCEGRRLKKRKTSIK 460

  Fly   556 WRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRL 620
            ..||||.|||...|:....::....||:.|.|.|....|:.:|..::|:.:.|...:.|...:..
Zfish   461 KNTLNPTYNEALVFDIPNENIESVSLIIAVMDYDCIGHNEVIGMCRMGSDADGPGREHWTAMLAN 525

  Fly   621 PDHFHEKWHCLAPD 634
            |....|.||.|..:
Zfish   526 PRKPIEHWHQLVEE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	43/147 (29%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	46/131 (35%)
syt3	XP_005164031.1	C2A_Synaptotagmin-1-5-6-9-10	269..394	CDD:176031	44/133 (33%)
syt3	XP_005164031.1	C2B_Synaptotagmin-3-5-6-9-10	403..536	CDD:176048	47/132 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910