DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg8a and FMN1

DIOPT Version :9

Sequence 1:	NP_727447.1	Gene:	Atg8a / 32001	FlyBaseID:	FBgn0052672	Length:	121	Species:	Drosophila melanogaster
Sequence 2:	NP_001264242.1	Gene:	FMN1 / 342184	HGNCID:	3768	Length:	1419	Species:	Homo sapiens

Alignment Length:	105	Identity:	27/105 - (25%)
Similarity:	47/105 - (44%)	Gaps:	22/105 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EHAFEKRRAEGDKIRRKYPDRVPVIVEKAPKAR--IGDLDKKKYLVPSDLTVGQFYFLIRKRIHL 70
            |:.|.|...:    ::|.|  :....||..|.:  |..||.|:     ..|||    ::...:||
Human  1019 EYLFSKDTTQ----QKKKP--LSETYEKKNKVKKIIKLLDGKR-----SQTVG----ILISSLHL 1068

  Fly    71 RPED---ALFFFVNNVIPPTSATMGSLYQEHHEEDYFLYI 107
            ..:|   |:|...::|:  ...|:.:||:...:||..:.|
Human  1069 EMKDIQQAIFNVDDSVV--DLETLAALYENRAQEDELVKI 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg8a	NP_727447.1	GABARAP	5..116	CDD:176355	27/105 (26%)
FMN1	NP_001264242.1	Microtubule-binding. /evidence=ECO:0000250	1..622
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..194
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..331
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..641
		Mediates interaction with alpha-catenin. /evidence=ECO:0000250	456..842
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..711
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..978
		FH2	973..1370	CDD:214697	27/105 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1390..1419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1654
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900