DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTBD9 and Klhl11

DIOPT Version :9

Sequence 1:	NP_001259431.1	Gene:	BTBD9 / 32000	FlyBaseID:	FBgn0030228	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	NP_001099308.1	Gene:	Klhl11 / 287706	RGDID:	1306673	Length:	709	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	98/430 - (22%)
Similarity:	174/430 - (40%)	Gaps:	108/430 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SGGGKKGAMEQDY---TDVVDLGDRFSADMARLCMNEQ-----YADV----------EFIVEEER 56
            :|||..|...:|:   |...:|..|         .|||     :.|:          ||
  Rat    60 TGGGDPGPEAEDFECSTHCSELSWR---------QNEQRRQGLFCDITLCFGGAGGREF------ 109

  Fly    57 IPAHRVILAARSEYFRALLYGGMAETTQRQI--------PLEVPLEAFKVLLRYIYSGTLLLSTL 113
             .|||.:|||.:|||..||.|..:|:...::        |...| :..:.::.|:|:|.:.:||
  Rat   110 -RAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEP-DTVEAVIEYMYTGRIRVST- 171

  Fly   114 DEDSTIDVLGMANQYGFQDLEMAISNYLRQYLALDNVCMILDAARLYNLEELTEVCLMFMDRNAG 178
              .|..:||.:|:::....|:.....:|::.|.|.|...|...|.:|.|.:|.        ..|.
  Rat   172 --GSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLA--------LKAA 226

  Fly   179 DLLLHNSFNTLSKE---SLEEVLRRDCFFAPEVQI------FLAVWKWSRFNSNVD---FKSVVS 231
            |::..|.:..:..|   :|...|.||.....|:.:      |..|.||.:.|:...   |:.:..
  Rat   227 DMIRRNFYKVIQDEEFYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFK 291

  Fly   232 YVRLPLMNLEHLLQVVRPSGILDPDK-----ILDAIDERSTSKALPYRAALWPEENVAAETFLSR 291
            .:||..|...:|.:.|:|..::..::     :.:|: ||...:|          ||:.:.|....
  Rat   292 LLRLSQMKPTYLTRHVKPERLVANNEVCVKLVAEAV-ERHALRA----------ENIQSGTLQHP 345

  Fly   292 CIQ-------GECRDALL-DGDVTTYDMENG-YTRHCITDSKDAGIVVELGTFCMINHIRMLLWD 347
            ..|       |:..|.:: .|.|:    |.| |...|:      |..|:...:..:.||...|
  Rat   346 TSQVSLLPRYGQNMDVIMVIGGVS----EGGDYLSECV------GYFVDEDRWVNLPHIHNHL-- 398

  Fly   348 RDSRAYSY---YVEVSGDQQ-HWDRVVDYSDYHCRSWQYL 383
             |..|.:.   ||.|:|..: .:.:.|:..:.:..:|:::
  Rat   399 -DGHAVAITESYVYVAGSMEPGFAKTVERYNPNLNTWEHV 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTBD9	NP_001259431.1	BTB	42..141	CDD:279045	31/121 (26%)
		BTB	47..145	CDD:197585	29/115 (25%)
		BACK_BTBD9_like	145..203	CDD:269811	16/60 (27%)
		F5_F8_type_C	299..399	CDD:304887	20/91 (22%)
		F5_F8_type_C	451..554	CDD:279139
Klhl11	NP_001099308.1	BTB_POZ_KLHL11	72..206	CDD:349550	37/153 (24%)
		PHA03098	91..554	CDD:222983	87/390 (22%)
		BACK_KLHL11	201..288	CDD:350526	23/94 (24%)
		KELCH repeat	400..440	CDD:276965	7/38 (18%)
		KELCH repeat	444..489	CDD:276965
		KELCH repeat	492..542	CDD:276965
		KELCH repeat	568..650	CDD:276965
		Kelch	612..658	CDD:128874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930