DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXA3 and Antp

DIOPT Version :9

Sequence 1:	NP_001371264.1	Gene:	HOXA3 / 3200	HGNCID:	5104	Length:	443	Species:	Homo sapiens
Sequence 2:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster

Alignment Length:	405	Identity:	105/405 - (25%)
Similarity:	134/405 - (33%)	Gaps:	186/405 - (45%)

- Green bases have known domain annotations that are detailed below.

Human     5 TYYDSSAIYGGYP--------YQAANGFAYNANQQ---PYPASA---------ALGADGE----- 44
            :|..:...:|.||        .|..:.::.|||.|   |||...         ..|.|.:
  Fly    18 SYMGADMHHGHYPGNGVTDLDAQQMHHYSQNANHQGNMPYPRFPPYDRMPYYNGQGMDQQQQHQV 82

Human    45 YHRPACSLQSPSS-AGG------------------------------------------------ 60
            |.||    .|||| .||
  Fly    83 YSRP----DSPSSQVGGVMPQAQTNGQLGVPQQQQQQQQQPSQNQQQQQAQQAPQQLQQQLPQVT 143

Human    61 ----HPKAHE----LSEAC-LRTLSAPPSQPPSLGEPPL-----------------HPPPPQA-- 97
                ||:..:    :..:| |:.........|..|.|||                 |...|||
  Fly   144 QQVTHPQQQQQQPVVYASCKLQAAVGGLGMVPEGGSPPLVDQMSGHHMNAQMTLPHHMGHPQAQL 208

Human    98 ----------------------------APPAPQPP-------QPAPQPPAPTPAAPPPPSSASP 127
                                        .||...||       |..||.....|....|||. :|
  Fly   209 GYTDVGVPDVTEVHQNHHNMGMYQQQSGVPPVGAPPQGMMHQGQGPPQMHQGHPGQHTPPSQ-NP 272

Human   128 PQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSGESCAGDKSPPGQASSK 192
            ...:|..|:|                 ::|||:......:::                      |
  Fly   273 NSQSSGMPSP-----------------LYPWMRSQFGKCQER----------------------K 298

Human   193 RARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLT 257
            |.|..||..|.:||||||||||||.|.||:|:|:.|.||||||||||||||||:||:.|.||. .
  Fly   299 RGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTKGE-P 362

Human   258 SSGGQ----SPSRSP 268
            .|||:    :|..||
  Fly   363 GSGGEGDEITPPNSP 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXA3	NP_001371264.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..147		24/125 (19%)
		Antp-type hexapeptide	155..160		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..196		3/36 (8%)
		Homeobox	195..248	CDD:395001	38/52 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..338		11/26 (42%)
		DUF4074	378..441	CDD:404218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..443
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	33/184 (18%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	38/52 (73%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810