DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXA3 and ftz

DIOPT Version :9

Sequence 1:	NP_001371264.1	Gene:	HOXA3 / 3200	HGNCID:	5104	Length:	443	Species:	Homo sapiens
Sequence 2:	NP_477498.1	Gene:	ftz / 40834	FlyBaseID:	FBgn0001077	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	413	Identity:	105/413 - (25%)
Similarity:	144/413 - (34%)	Gaps:	164/413 - (39%)

- Green bases have known domain annotations that are detailed below.

Human     5 TYYDSSAIYGGY-PYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGGHPKAHELS 68
            :|.|:..:|..| |:.....:..|:....|                  .|:.|:..|:......|
  Fly    11 SYADNMNMYNMYHPHSLPPTYYDNSGSNAY------------------YQNTSNYQGYYPQESYS 57

Human    69 EAC--------LRTLSAPPSQPPSLGEPPLHPPPPQA---------------------------- 97
            |:|        :.|.:.||.||.:        |||:|
  Fly    58 ESCYYYNNQEQVTTQTVPPVQPTT--------PPPKATKRKAEDDAASIIAAVEERPSTLRALLT 114

Human    98 -------------------------------APPAPQPPQPAPQPPAPTP--------------- 116
                                           |.|||...|.....|.|:.
  Fly   115 NPVKKLKYTPDYFYTTVEQVKKAPAVSTKVTASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQSQ 179

Human   117 ---------AAPPPPSSAS-PPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTS 171
                     |.|||.:..| ||....:.|..:...||    |..|:::|         |.:..|:
  Fly   180 TQKLKNGDFATPPPTTPTSLPPLEGISTPPQSPGEKS----SSAVSQEI---------NHRIVTA 231

Human   172 SSSSG--------ESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLL 228
            .:.:|        |:.|.|..     .|||.|..||..|.:|||||||||||:.|.||:::||.|
  Fly   232 PNGAGDFNWSHIEETLASDCK-----DSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANAL 291

Human   229 NLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAG--GYLNSMHSLVNSVPYEP 291
            :|:||||||||||||||.|||            ::...||...|||  ..|..:.:...:....|
  Fly   292 SLSERQIKIWFQNRRMKSKKD------------RTLDSSPEHCGAGYTAMLPPLEATSTATTGAP 344

Human   292 QSPPPFSKPPQGTYGLPPASYPA 314
            ..|.|.....|.|     |:|||
  Fly   345 SVPVPMYHHHQTT-----AAYPA 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXA3	NP_001371264.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..147		25/155 (16%)
		Antp-type hexapeptide	155..160		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..196		9/44 (20%)
		Homeobox	195..248	CDD:395001	36/52 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..338		18/70 (26%)
		DUF4074	378..441	CDD:404218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..443
ftz	NP_477498.1	FTZ	1..248	CDD:281812	46/275 (17%)
ftz	NP_477498.1	Homeobox	257..310	CDD:278475	36/52 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810