DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXA3 and zen2

DIOPT Version :9

Sequence 1:	NP_001371264.1	Gene:	HOXA3 / 3200	HGNCID:	5104	Length:	443	Species:	Homo sapiens
Sequence 2:	NP_476794.1	Gene:	zen2 / 40827	FlyBaseID:	FBgn0004054	Length:	252	Species:	Drosophila melanogaster

Alignment Length:	171	Identity:	61/171 - (35%)
Similarity:	79/171 - (46%)	Gaps:	46/171 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   132 SNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSGESCAGDKSPPGQASSKRART 196
            |.|....|.:.|.|:..|.|...:          ....|:::.|.|            .|||:||
  Fly     6 SENYFVDNYSVSDLMMYPCVELNV----------EAAPTATTRSSE------------KSKRSRT 48

Human   197 AYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGG 261
            |::|.||:|||:|||.|:||.|.||:|::..|.|||||:||||||||||.||....||.:
  Fly    49 AFSSLQLIELEREFHLNKYLARTRRIEISQRLALTERQVKIWFQNRRMKLKKSTNRKGAI----- 108

Human   262 QSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSKPPQ 302
                      ||         |..|:|...||.....|..|
  Fly   109 ----------GA---------LTTSIPLSSQSSEDLQKDDQ 130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXA3	NP_001371264.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..147		5/14 (36%)
		Antp-type hexapeptide	155..160		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..196		6/36 (17%)
		Homeobox	195..248	CDD:395001	35/52 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..338		13/56 (23%)
		DUF4074	378..441	CDD:404218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..443
zen2	NP_476794.1	Homeobox	46..99	CDD:278475	35/52 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770