DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11Lbeta and APBA3

DIOPT Version :9

Sequence 1:	NP_727440.3	Gene:	X11Lbeta / 31997	FlyBaseID:	FBgn0052677	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	XP_006723013.1	Gene:	APBA3 / 9546	HGNCID:	580	Length:	650	Species:	Homo sapiens

Alignment Length:	303	Identity:	156/303 - (51%)
Similarity:	205/303 - (67%)	Gaps:	15/303 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly  1772 LIEGVLFRAKYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPDGDVQPSTEVDLFISTEKIMV 1836
            |::||:|.|:||||||||.|..|..||||.||.||:.|:|  ||||:.||.||||||:||::|.|
Human   215 LLDGVIFGARYLGSTQLVSERNPPTSTRMAQAREAMDRVK--APDGETQPMTEVDLFVSTKRIKV 277

  Fly  1837 LNTDLKEIMMDHALRTISYIADIGDLVVLMARRRF----VPQDIDDAPKPNRTPKMICHVFESDE 1897
            |..|.:|.||||||.||||.||||.::|||||||.    .|||     ...|..||:||||.:::
Human   278 LTADSQEAMMDHALHTISYTADIGCVLVLMARRRLARRPAPQD-----HGRRLYKMLCHVFYAED 337

  Fly  1898 AQFIAQSIGQAFQVAYMEFLKANGIEDHRFVKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVP 1962
            ||.|||:|||||..||.:||:.:||:.    .::.......:..:...:|:.|:..:..:||.:.
Human   338 AQLIAQAIGQAFAAAYSQFLRESGIDP----SQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLE 398

  Fly  1963 KAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGLSLVGLPLSTCQTY 2027
            |.:||.|||.:|||||||:|||.|||||:..|.|.|.|.|:|||:|.||||.|||||||:.||..
Human   399 KRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAA 463

  Fly  2028 IKNTKNQTVVKFTVVPCAPVVEVKIKRPETKYQLGFSVQNGVI 2070
            ::.||:||.|..::|.|.||....|.||..:.||||.|::|::
Human   464 VRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919	91/155 (59%)
		PDZ_signaling	1957..2042	CDD:238492	50/84 (60%)
		PDZ_signaling	2047..2120	CDD:238492	10/24 (42%)
APBA3	XP_006723013.1	PTB_X11	212..364	CDD:269919	91/155 (59%)
APBA3	XP_006723013.1	PDZ	394..477	CDD:278991	50/82 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002645
OrthoInspector	1	1.000	-	-		mtm8492
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2607
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.830