DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11Lbeta and Apba3

DIOPT Version :9

Sequence 1:	NP_727440.3	Gene:	X11Lbeta / 31997	FlyBaseID:	FBgn0052677	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	XP_006241080.1	Gene:	Apba3 / 83611	RGDID:	620846	Length:	636	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	212/539 - (39%)
Similarity:	288/539 - (53%)	Gaps:	86/539 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1678 PGGAVKLSEQEIGT------INGGSVMPLGSGSGTGSGAGSGAGSGTGTNAAVVANSNANNNVGG 1736
            |.|...|||.|:.|      :.....:|...|.....||.......||...|...|.:|...:..
  Rat    41 PRGPDTLSEMELDTSSVRALVQQLEALPSDLGGQFPDGAPCPLHIATGQGLATQENLDAGGLLSA 105

  Fly  1737 GGGGGN-------------------------------NSSGSGAG-----------SNSNSGEKK 1759
            ..||.|                               ...|...|           |:|:|.|..
  Rat   106 EAGGDNLLGLLRCEASLPAQSVPPDPAQAAPRLLQPPEDPGGDPGWMEGTEPADNRSSSSSPELW 170

  Fly  1760 VKK------------SKSKE---------------GGAVLIEGVLFRAKYLGSTQLVCEGQPTKS 1797
            ::.            ::|:|               |...|::||||.|||||||||:.|..|..|
  Rat   171 LETAPLVTHRDPPVGTQSQETLASCPAVSEVPGPCGQEELMDGVLFGAKYLGSTQLLSERNPPPS 235

  Fly  1798 TRMMQAEEAVSRIKALAPDGDVQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDL 1862
            |||.||:||:.|:|  ||:|:.||.||||:||||:::.||..|.::.:|||||:|||||||||.:
  Rat   236 TRMGQAQEAMDRVK--APEGETQPMTEVDIFISTKRVKVLAADSQDALMDHALQTISYIADIGPV 298

  Fly  1863 VVLMARRRFVPQDIDDAPKPNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIEDHRF 1927
            :|||||||...:.... .:..:..||:||||.|::||.|||:|||||.:||.:||:.|.|:.
  Rat   299 LVLMARRRLAKRTTSQ-DRQRQLYKMLCHVFHSEDAQLIAQAIGQAFSIAYSQFLQENRIDP--- 359

  Fly  1928 VKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMS 1992
             .::..|...::......:|:.|...:..:||.:.|..||.|||.:|||||||:|||.|||||:.
  Rat   360 -SQVGMQPSASASHPHNGDLDHFCNSQNCREVCIQKRPGEGLGVALVESGWGSLLPTAVIANLLH 423

  Fly  1993 SGAAARCGQLNIGDQLIAINGLSLVGLPLSTCQTYIKNTKNQTVVKFTVVPCAPVVEVKIKRPET 2057
            .|.|.|||.|:|||::.||||.|||||.|:.||..::..:..:.|..:::.|.||....|.||..
  Rat   424 GGPAERCGALSIGDRVTAINGTSLVGLSLAACQAAVREVRRHSSVTLSIIHCPPVTTAVIHRPHV 488

  Fly  2058 KYQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVNLLATS----VGEIL 2118
            :.||||.|:||:|||||||..||||||||||||||:|.|||||:||.:|:.||..:    ||.:.
  Rat   489 REQLGFCVENGIICSLLRGSAAERGGVRVGHRIIEVNGQSVVAMPHARIIQLLTETREVCVGHLT 553

  Fly  2119 MKTMPTSMFRLLTGQENPI 2137
            ....|.:....|....:|:
  Rat   554 RSPDPVTNTLTLLPDSSPL 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919	86/153 (56%)
		PDZ_signaling	1957..2042	CDD:238492	45/84 (54%)
		PDZ_signaling	2047..2120	CDD:238492	45/76 (59%)
Apba3	XP_006241080.1	PTB_X11	208..359	CDD:269919	86/153 (56%)
		PDZ_signaling	388..473	CDD:238492	45/84 (54%)
		PDZ_signaling	478..549	CDD:238492	43/70 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002645
OrthoInspector	1	1.000	-	-		mtm8963
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12345
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.800