DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11Lbeta and Apba2

DIOPT Version :9

Sequence 1:	NP_727440.3	Gene:	X11Lbeta / 31997	FlyBaseID:	FBgn0052677	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	NP_113968.1	Gene:	Apba2 / 83610	RGDID:	620845	Length:	750	Species:	Rattus norvegicus

Alignment Length:	913	Identity:	345/913 - (37%)
Similarity:	441/913 - (48%)	Gaps:	217/913 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1274 TTASTTTDSNGGVGGVGHHLVATLVASPNNEQAKSQCQTQLQSHPPKTLSLDQSPSNHSKVFKNI 1338
            :|||:..|.....|.:.|.      ..|.||..    :..|:|:.|..|
  Rat     8 STASSMLDHRARPGPIPHD------QEPENEDT----ELPLESYVPTGL---------------- 46

  Fly  1339 DPELDSLYSIGVFHRPDTVQMTPPPPAPAPHRKPNNNGCSSGVVNTNGSLAGGSNDVDLLQPSSK 1403
              ||.:|       |||    :|.|.....|....:...||..||....    ..|.|...|..:
  Rat    47 --ELGTL-------RPD----SPTPEEQECHNHSPDGDSSSDYVNNTSE----EEDYDEGLPEEE 94

  Fly  1404 -----HTPLAAAISSTLQRSSPTSTITGNGIGNGSGKTRSAGSNCSSS---ANGGMPPPIPERTN 1460
                 :........|.|:                       |.:|:..   |:|..|....|...
  Rat    95 EGVTYYIRYCPEDDSYLE-----------------------GMDCNGEEYLAHGAHPVDTDECQE 136

  Fly  1461 LVSAVQRSPSPGPNSPVWLSRHLDGGAGKDLLESGSDNHSKNHSADEEDVDTDLETDRLLGHQRL 1525
            .|.  ..:.|.||::      |..|.       ..|..:..:|....||..|.||.     |.:.
  Rat   137 AVE--DWTDSVGPHT------HSHGA-------ENSQEYPDSHLPIPEDDPTVLEV-----HDQE 181

  Fly  1526 DDQGYYDENKSWDRKPRSLLSKISPKQQIPSTKTRNGYNALLSSTPELPPPIPPK--GQSGLGLG 1588
            :| |:|                      .||.::...|             .||:  |.:|....
  Rat   182 ED-GHY----------------------CPSKESYQDY-------------YPPETNGNTGGASP 210

  Fly  1589 LTLGAGNGG-----KLLDLVGGMVQRSLSRSS-SEHSEKSLSKMP-ISGGDLCAGGVDVVASTVA 1646
            ..:..|:|.     :.:|.:...::.|||.:| :..||.|...|| :..||
  Rat   211 YRMRRGDGDLEEQEEDIDQIVAEIKMSLSMTSITSASEASPEHMPELDPGD-------------- 261

  Fly  1647 ATSATVVASTPALGSPGNGGGSERSAAEMANPGGAVKLSEQEIGTINGGSVMPLGSGSGTGSGAG 1711
                    ||.|......|.|..|   :.|.|...              ::.|....||...
  Rat   262 --------STEACSPSDTGRGPSR---QEARPKSL--------------NLPPEVKHSGDPQ--- 298

  Fly  1712 SGAGSGTGTNAAVVANSNANNNVGGG---GGGGNNSSGSGAGSNSNSGEKKVKKSKSKEGGAV-- 1771
              .|..|.|.............|..|   ......|..:|...|:|..|.| |.:......||
  Rat   299 --RGLKTKTRTPEERPKWPQEQVCNGLEQPRKQQRSDLNGPTDNNNIPETK-KVASFPSFVAVPG 360

  Fly  1772 ------LIEGVLFRAKYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALA----------PDGDVQ 1820
                  ||:|::|.|.|||||||:.|..|:|:.|||||:|||||:|.:.          .:||.|
  Rat   361 PCEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQ 425

  Fly  1821 PSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRF---VPQD-IDDAP- 1880
            ..|||||||||::|.|||.|.:|.||||||||||||||||::||||||||.   ..|| |:..|
  Rat   426 TLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPG 490

  Fly  1881 --KPNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGI--EDHRFVKEMDYQEVLNSQE 1941
              :..:..|||||||||::||.|||||||||.|||.|||:||||  ||   :.:.:|.:::|:||
  Rat   491 AQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPED---LSQKEYSDIINTQE 552

  Fly  1942 IFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGD 2006
            ::.|:|..|:..|..||:.:.|.||||||||:|||||||:||||::||:|:.|.|||.|:|:|||
  Rat   553 MYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGD 617

  Fly  2007 QLIAINGLSLVGLPLSTCQTYIKNTKNQTVVKFTVVPCAPVVEVKIKRPETKYQLGFSVQNGVIC 2071
            |:::|||.|||||||:|||..||..||||.||..:|.|.||..|.||||:.|||||||||||:||
  Rat   618 QIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIIC 682

  Fly  2072 SLLRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVNLLATSVGEILMKTMPTSMFRLLTGQENP 2136
            ||:||||||||||||||||||||.|||||..|||||..|:.|||||.|||||.:|||||||||.|
  Rat   683 SLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETP 747

  Fly  2137 IYI 2139
            :||
  Rat   748 LYI 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919	104/180 (58%)
		PDZ_signaling	1957..2042	CDD:238492	56/84 (67%)
		PDZ_signaling	2047..2120	CDD:238492	57/72 (79%)
Apba2	NP_113968.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94		29/128 (23%)
		MSCRAMM_ClfB	<20..303	CDD:411414	83/448 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..226		25/136 (18%)
		STXBP1-binding	185..271		25/142 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..347		29/149 (19%)
		PTB_X11	364..536	CDD:269919	102/171 (60%)
		PDZ	569..652	CDD:395476	55/82 (67%)
		PDZ_signaling	658..731	CDD:238492	57/72 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349383
Domainoid	1	1.000	172	1.000	Domainoid score	I3621
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	504	1.000	Inparanoid score	I1292
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002645
OrthoInspector	1	1.000	-	-		mtm8963
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	O	PTHR12345
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.750