Protein Alignment X11Lbeta and Apba2

DIOPT Version :10

• Sequence 1: NP_727440.3
• Gene: X11Lbeta / 31997
• FlyBaseID: FBgn0052677
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: NP_113968.1
• Gene: Apba2 / 83610
• RGDID: 620845
• Length: 750
• Species: Rattus norvegicus
• Alignment Length: 913
• Identity: 345/913 - (37%)
• Similarity: 441/913 - (48%)
• Gaps: 217/913 - (23%)

  Fly  1274 TTASTTTDSNGGVGGVGHHLVATLVASPNNEQAKSQCQTQLQSHPPKTLSLDQSPSNHSKVFKNI 1338
            :|||:..|.....|.:.|.      ..|.||..    :..|:|:.|..|
  Rat     8 STASSMLDHRARPGPIPHD------QEPENEDT----ELPLESYVPTGL---------------- 46

  Fly  1339 DPELDSLYSIGVFHRPDTVQMTPPPPAPAPHRKPNNNGCSSGVVNTNGSLAGGSNDVDLLQPSSK 1403
              ||.:|       |||    :|.|.....|....:...||..||....    ..|.|...|..:
  Rat    47 --ELGTL-------RPD----SPTPEEQECHNHSPDGDSSSDYVNNTSE----EEDYDEGLPEEE 94

  Fly  1404 -----HTPLAAAISSTLQRSSPTSTITGNGIGNGSGKTRSAGSNCSSS---ANGGMPPPIPERTN 1460
                 :........|.|:                       |.:|:..   |:|..|....|...
  Rat    95 EGVTYYIRYCPEDDSYLE-----------------------GMDCNGEEYLAHGAHPVDTDECQE 136

  Fly  1461 LVSAVQRSPSPGPNSPVWLSRHLDGGAGKDLLESGSDNHSKNHSADEEDVDTDLETDRLLGHQRL 1525
            .|.  ..:.|.||::      |..|.       ..|..:..:|....||..|.||.     |.:.
  Rat   137 AVE--DWTDSVGPHT------HSHGA-------ENSQEYPDSHLPIPEDDPTVLEV-----HDQE 181

  Fly  1526 DDQGYYDENKSWDRKPRSLLSKISPKQQIPSTKTRNGYNALLSSTPELPPPIPPK--GQSGLGLG 1588
            :| |:|                      .||.::...|             .||:  |.:|....
  Rat   182 ED-GHY----------------------CPSKESYQDY-------------YPPETNGNTGGASP 210

  Fly  1589 LTLGAGNGG-----KLLDLVGGMVQRSLSRSS-SEHSEKSLSKMP-ISGGDLCAGGVDVVASTVA 1646
            ..:..|:|.     :.:|.:...::.|||.:| :..||.|...|| :..||
  Rat   211 YRMRRGDGDLEEQEEDIDQIVAEIKMSLSMTSITSASEASPEHMPELDPGD-------------- 261

  Fly  1647 ATSATVVASTPALGSPGNGGGSERSAAEMANPGGAVKLSEQEIGTINGGSVMPLGSGSGTGSGAG 1711
                    ||.|......|.|..|   :.|.|...              ::.|....||...
  Rat   262 --------STEACSPSDTGRGPSR---QEARPKSL--------------NLPPEVKHSGDPQ--- 298

  Fly  1712 SGAGSGTGTNAAVVANSNANNNVGGG---GGGGNNSSGSGAGSNSNSGEKKVKKSKSKEGGAV-- 1771
              .|..|.|.............|..|   ......|..:|...|:|..|.| |.:......||
  Rat   299 --RGLKTKTRTPEERPKWPQEQVCNGLEQPRKQQRSDLNGPTDNNNIPETK-KVASFPSFVAVPG 360

  Fly  1772 ------LIEGVLFRAKYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALA----------PDGDVQ 1820
                  ||:|::|.|.|||||||:.|..|:|:.|||||:|||||:|.:.          .:||.|
  Rat   361 PCEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQ 425

  Fly  1821 PSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRF---VPQD-IDDAP- 1880
            ..|||||||||::|.|||.|.:|.||||||||||||||||::||||||||.   ..|| |:..|
  Rat   426 TLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPG 490

  Fly  1881 --KPNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGI--EDHRFVKEMDYQEVLNSQE 1941
              :..:..|||||||||::||.|||||||||.|||.|||:||||  ||   :.:.:|.:::|:||
  Rat   491 AQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPED---LSQKEYSDIINTQE 552

  Fly  1942 IFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGD 2006
            ::.|:|..|:..|..||:.:.|.||||||||:|||||||:||||::||:|:.|.|||.|:|:|||
  Rat   553 MYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGD 617

  Fly  2007 QLIAINGLSLVGLPLSTCQTYIKNTKNQTVVKFTVVPCAPVVEVKIKRPETKYQLGFSVQNGVIC 2071
            |:::|||.|||||||:|||..||..||||.||..:|.|.||..|.||||:.|||||||||||:||
  Rat   618 QIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIIC 682

  Fly  2072 SLLRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVNLLATSVGEILMKTMPTSMFRLLTGQENP 2136
            ||:||||||||||||||||||||.|||||..|||||..|:.|||||.|||||.:|||||||||.|
  Rat   683 SLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETP 747

  Fly  2137 IYI 2139
            :||
  Rat   748 LYI 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919	104/180 (58%)
		PDZ1_APBA1_3-like	1957..2042	CDD:467203	56/84 (67%)
		PDZ2_APBA1_3-like	2046..2123	CDD:467255	61/76 (80%)
Apba2	NP_113968.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..94		29/128 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	143..226		25/136 (18%)
		STXBP1-binding	185..271		25/142 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..347		29/149 (19%)
		PTB_X11	364..536	CDD:269919	102/171 (60%)
		PDZ1_APBA1_3-like	568..653	CDD:467203	56/84 (67%)
		PDZ2_APBA1_3-like	657..734	CDD:467255	61/76 (80%)