DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11Lbeta and Apba1

DIOPT Version :9

Sequence 1:	NP_727440.3	Gene:	X11Lbeta / 31997	FlyBaseID:	FBgn0052677	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	NP_113967.2	Gene:	Apba1 / 83589	RGDID:	620844	Length:	841	Species:	Rattus norvegicus

Alignment Length:	982	Identity:	347/982 - (35%)
Similarity:	466/982 - (47%)	Gaps:	252/982 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1269 MNNQTTTASTTTDSNGGVGGVGHHLVATLVASPNNEQAKSQCQTQLQSHPPKTLSLDQSPSNHSK 1333
            ||:...:|..........|.|...:.|.|      |..:.:.:.|.|..||       .|:.|:
  Rat     1 MNHLEGSAEVEVADEAPGGEVNESVEADL------EHPEVEEEQQPQPSPP-------PPAGHA- 51

  Fly  1334 VFKNIDPELDSLYSIGVFHRPDTVQMTPPPPAPAPHRKPNNNGCSSGVVNTNGSLAGGSNDVDLL 1398
                  ||         .||   ....||||.|....:.....|.:...:|.   :|..|..|
  Rat    52 ------PE---------DHR---AHPAPPPPPPPQEEEEERGECLARSASTE---SGFHNHTD-- 93

  Fly  1399 QPSSKHTPLAAAISSTLQRSSPTSTITGNGIGNGSGKTRSAGSNCSSSANGGMPPPIPERTNLVS 1463
              :::...||||                   .:|....|:..::..|:                .
  Rat    94 --TAEGDVLAAA-------------------RDGYEAERAQDADDESA----------------Y 121

  Fly  1464 AVQRSPSPGPNSPVWLSRHLDGGAGKDLLESGSDNHSKNHSADEEDVDTDLETDRLLGHQ---RL 1525
            |||..|.....:....:.|.:....:.|     .||...||.:.|:......:..:..|:   |.
  Rat   122 AVQYRPEAEEYTEQAEAEHAEAAQRRAL-----PNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRA 181

  Fly  1526 DDQGYYDENKSWDRKPRSLLSKISPKQQIPSTKTRNG------------------YNALL----- 1567
            :|:.|.:....:......:..:|.   ..|..:.|:|                  ..|.|
  Rat   182 EDEPYAEPYADYGGLQEHVYEEIG---DAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDE 243

  Fly  1568 -----SSTPELPPPIPPKGQSGLGLGLTLGAGNGGKLLDLVGGMVQRSLSRSSSE-------HSE 1620
                 |.:||......|..:        :.:....:.:|.:...|::|:|..|.:       .:|
  Rat   244 RSDGESDSPEKEAEFAPYPR--------MDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAE 300

  Fly  1621 KSLSKMPISGGDLCAGGVDVVASTVAATSATVVASTPALGSPGNGGGSE---------RSAAEMA 1676
            :.|.:.|..||    |..|.......|.....|..||        ||||         |.|..:|
  Rat   301 QDLERAPTPGG----GHPDSPGLPAPAGQQQRVVGTP--------GGSEVGQRYSKEKRDAISLA 353

  Fly  1677 -----------------------NPGGAVKLSEQEIG---------TINGGSVMPLGSGSGTGSG 1709
                                   .|...:.:..|:|.         .::|.|..|   ||.:..|
  Rat   354 IKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSP---GSSSPLG 415

  Fly  1710 AGSG---AGSGTGTNAAVVANSNANNNVGGGGGGGNNSSGSGAGSNSNSGEKKVKKSKSKEGGAV 1771
            |.|.   ...|..|.|                                |..|:.:||.:.....|
  Rat   416 AESSITPLHPGDPTEA--------------------------------STNKESRKSLASFPTYV 448

  Fly  1772 ----------LIEGVLFRAKYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKAL---------APDG 1817
                      ||:|::|.|.|||||||:.:..|:|:.|||||:|||||||..         ||:|
  Rat   449 EVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEG 513

  Fly  1818 DVQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVP----QDIDD 1878
            :.||.|||||||||::|.|||.|.:|.||||.|||||||||||::|||||||| :|    |:..:
  Rat   514 ESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRR-MPRSNSQENVE 577

  Fly  1879 APKPN----RTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGI--EDHRFVKEMDYQEVL 1937
            |..|:    |..|||||||||::||.|||||||||.|||.|||:||||  ||   :.:.:|.::|
  Rat   578 ASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPED---LSQKEYSDLL 639

  Fly  1938 NSQEIFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQL 2002
            |:|:::.|:|..|:|.|..|:|.:.|.||||||||||||||||:||||:|||:|..|.|.:.|:|
  Rat   640 NTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKL 704

  Fly  2003 NIGDQLIAINGLSLVGLPLSTCQTYIKNTKNQTVVKFTVVPCAPVVEVKIKRPETKYQLGFSVQN 2067
            |||||:::|||.|||||||||||:.||..|||:.||..:|.|.||..|.|:||:.:|||||||||
  Rat   705 NIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQN 769

  Fly  2068 GVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVNLLATSVGEILMKTMPTSMFRLLTG 2132
            |:||||:||||||||||||||||||||.|||||.||||||::|:.:||||.|||||.:|:||||.
  Rat   770 GIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTA 834

  Fly  2133 QENPIYI 2139
            ||.|:||
  Rat   835 QEQPVYI 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919	105/182 (58%)
		PDZ_signaling	1957..2042	CDD:238492	57/84 (68%)
		PDZ_signaling	2047..2120	CDD:238492	55/72 (76%)
Apba1	NP_113967.2	Munc-18-1 binding	229..317		18/99 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..348		25/130 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..439		16/109 (15%)
		LIN-2/CASK binding	377..440		16/97 (16%)
		PTB_X11	456..627	CDD:269919	104/171 (61%)
		Autoinhibitory helix linker	630..645		4/14 (29%)
		PDZ	660..743	CDD:395476	56/82 (68%)
		PDZ_signaling	749..822	CDD:238492	55/72 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349384
Domainoid	1	1.000	172	1.000	Domainoid score	I3621
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	504	1.000	Inparanoid score	I1292
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8963
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	LDO	PTHR12345
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.750