DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment X11Lbeta and APBA2

DIOPT Version :9

Sequence 1:NP_727440.3 Gene:X11Lbeta / 31997 FlyBaseID:FBgn0052677 Length:2139 Species:Drosophila melanogaster
Sequence 2:NP_001340717.1 Gene:APBA2 / 321 HGNCID:579 Length:749 Species:Homo sapiens


Alignment Length:783 Identity:312/783 - (39%)
Similarity:402/783 - (51%) Gaps:173/783 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1455 IPERTNLVSAVQRSPSPGPNSPVWLSRHLDGGAGKDLLESGSDNHSKNHSADEED---------- 1509
            :||...|  |..|..||.|......:...||.:..|.:.:.|:....:....||:          
Human    42 VPEGLEL--AALRPESPAPEEQECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYC 104

  Fly  1510 ------------------------VDTDLETDRLL------------GHQRLDDQGYYDENKSWD 1538
                                    |||| |....:            ||:....|.|.|......
Human   105 PEDDSYLEGMDCNGEEYLAHSAHPVDTD-ECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIP 168

  Fly  1539 RKPRSLLSKISPKQQIPSTKTRNGYNALLSSTPELPPPIPPKGQSGLGLGLTLGAGNGG-----K 1598
            ....|:|.....::......::.||....        |....|.:|.. ...|..|:|.     :
Human   169 EDEPSVLEAHDQEEDGHYCASKEGYQDYY--------PEEANGNTGAS-PYRLRRGDGDLEDQEE 224

  Fly  1599 LLDLVGGMVQRSLSRSS-SEHSEKSLSKMPISGGDLCAGGVDVVASTVAATSATVVASTPAL--- 1659
            .:|.:...::.|||.:| :..||.|....|..|.:   ..|:......|:.|.:...:.|..   
Human   225 DIDQIVAEIKMSLSMTSITSASEASPEHGPEPGPE---DSVEACPPIKASCSPSRHEARPKSLNL 286

  Fly  1660 -------GSPGNGGGSERSAAE---------MANPGGAVKLSEQEIGTINGGSVMPLGSGSGTGS 1708
                   |.|..|...:....|         :.|  |..:..:|:...:||    |:.       
Human   287 LPEAKHPGDPQRGFKPKTRTPEERLKWPHEQVCN--GLEQPRKQQRSDLNG----PVD------- 338

  Fly  1709 GAGSGAGSGTGTNAAVVANSNANNNVGGGGGGGNNSSGSGAGSNSNSGEKKVKKSKSKEGGAV-- 1771
                                  |||:                    ...|||....|..  ||  
Human   339 ----------------------NNNI--------------------PETKKVASFPSFV--AVPG 359

  Fly  1772 ------LIEGVLFRAKYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALA----------PDGDVQ 1820
                  ||:|::|.|.|||||||:.|..|:|:.|||||:|||||:|.:.          .:||.|
Human   360 PCEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQ 424

  Fly  1821 PSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRF---VPQD-IDDAP- 1880
            ..|||||||||::|.|||.|.:|.||||||||||||||||::||||||||.   ..|| |:..| 
Human   425 TLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPG 489

  Fly  1881 --KPNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGI--EDHRFVKEMDYQEVLNSQE 1941
              :..:..|||||||||::||.|||||||||.|||.|||:||||  ||   :.:.:|.:::|:||
Human   490 AQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPED---LSQKEYSDIINTQE 551

  Fly  1942 IFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGD 2006
            ::.|:|..|:..|..||:.:.|.||||||||:|||||||:||||::||:|:.|.|||.|:|:|||
Human   552 MYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGD 616

  Fly  2007 QLIAINGLSLVGLPLSTCQTYIKNTKNQTVVKFTVVPCAPVVEVKIKRPETKYQLGFSVQNGVIC 2071
            |:::|||.|||||||:|||..||..||||.||..:|.|.||..|.||||:.|||||||||||:||
Human   617 QIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIIC 681

  Fly  2072 SLLRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVNLLATSVGEILMKTMPTSMFRLLTGQENP 2136
            ||:||||||||||||||||||||.|||||..|||||..|:.|||||.|||||.:|||||||||.|
Human   682 SLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETP 746

  Fly  2137 IYI 2139
            :||
Human   747 LYI 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
X11LbetaNP_727440.3 PTB_X11 1770..1924 CDD:269919 104/180 (58%)
PDZ_signaling 1957..2042 CDD:238492 56/84 (67%)
PDZ_signaling 2047..2120 CDD:238492 57/72 (79%)
APBA2NP_001340717.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..94 13/53 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 130..220 19/99 (19%)
STXBP1-binding 185..270 19/96 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 238..344 24/163 (15%)
PTB_X11 363..535 CDD:269919 102/171 (60%)
PDZ 568..651 CDD:395476 55/82 (67%)
PDZ_signaling 657..730 CDD:238492 57/72 (79%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155498
Domainoid 1 1.000 172 1.000 Domainoid score I3726
eggNOG 1 0.900 - - E1_KOG3605
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002645
OrthoInspector 1 1.000 - - mtm8492
orthoMCL 1 0.900 - - OOG6_104247
Panther 1 1.100 - - O PTHR12345
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2607
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.730

Return to query results.
Submit another query.