DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11Lbeta and APBA1

DIOPT Version :9

Sequence 1:	NP_727440.3	Gene:	X11Lbeta / 31997	FlyBaseID:	FBgn0052677	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	NP_001154.2	Gene:	APBA1 / 320	HGNCID:	578	Length:	837	Species:	Homo sapiens

Alignment Length:	884	Identity:	326/884 - (36%)
Similarity:	445/884 - (50%)	Gaps:	240/884 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1339 DPELDSLYSIGVFHRPDTVQMTPPPP---APAPHRK--PNN------------NGCSSGVVNTNG 1386
            |||.:|.|:  |.:||:..:.|....   |.|.||:  ||:            |...||.|.|:.
Human   111 DPEDESAYA--VQYRPEAEEYTEQAEAEHAEATHRRALPNHLHFHSLEHEEAMNAAYSGYVYTHR 173

  Fly  1387 SLAGGSNDVDLLQPSSKHTPLAAAISSTLQRSSPTSTITGNGIGNGSGKTRSAGSNCSSSANGGM 1451
            ....|.:     :|.|:  |.|                                      ..||:
Human   174 LFHRGED-----EPYSE--PYA--------------------------------------DYGGL 193

  Fly  1452 PPPIPERTNLVSAVQRSPSPGPNSPVWLSRHLDGGAGKDLLESGSDN-------------HSKNH 1503
            ...:.|...             ::|     .||...|..|.|...|.             |..:.
Human   194 QEHVYEEIG-------------DAP-----ELDARDGLRLYEQERDEAAAYRQEALGARLHHYDE 240

  Fly  1504 SADEEDVDTDLETDRLLGHQRLDDQGYYDENKSWDRKPRSLLSKISPKQQIPSTKTRNGYNALLS 1568
            .:|.|....:.|.: ...:.|:|.   |::.:..|:    :::::  ||.:.|       .:|..
Human   241 RSDGESDSPEKEAE-FAPYPRMDS---YEQEEDIDQ----IVAEV--KQSMSS-------QSLDK 288

  Fly  1569 STPELP--------PPIPPKG-------QSGLGLGLTLGAGNGGKLLDLVGGMVQRSLSRSSSEH 1618
            :..::|        ||.|..|       |:..|....:|...||:               :...:
Human   289 AAEDMPEAEQDLERPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGE---------------AGQRY 338

  Fly  1619 SEKSLSKMPISGGDLCAGGVDVVASTVAATSATVVASTPALGSPGNGGGSERSAAEMANPGGAVK 1683
            |::....:.::..|:.....:|...|:                        ||......|...:.
Human   339 SKEKRDAISLAIKDIKEAIEEVKTRTI------------------------RSPYTPDEPKEPIW 379

  Fly  1684 LSEQEIG---------TINGGSVMPLGSGSGTGSGAGSGAGSGTGTNAAVVANSNANNNVGGGGG 1739
            :..|:|.         .::|.|..|   ||.:..||.|   |.|..:.:....::.|
Human   380 VMRQDISPTRDCDDQRPMDGDSPSP---GSSSPLGAES---SSTSLHPSDPVEASTN-------- 430

  Fly  1740 GGNNSSGSGAGSNSNSGEKKVKKSKSKEGGAV----------LIEGVLFRAKYLGSTQLVCEGQP 1794
                              |:.:||.:.....|          ||:|::|.|.|||||||:.:..|
Human   431 ------------------KESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTP 477

  Fly  1795 TKSTRMMQAEEAVSRIKAL---------APDGDVQPSTEVDLFISTEKIMVLNTDLKEIMMDHAL 1850
            :|:.|||||:|||||||..         ||:|:.||.|||||||||::|.|||.|.:|.||||.|
Human   478 SKNVRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDHPL 542

  Fly  1851 RTISYIADIGDLVVLMARRRFVP----QDIDDAPKPN----RTPKMICHVFESDEAQFIAQSIGQ 1907
            ||||||||||::|||||||| :|    |:..:|..|:    |..|||||||||::||.|||||||
Human   543 RTISYIADIGNIVVLMARRR-MPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQ 606

  Fly  1908 AFQVAYMEFLKANGI--EDHRFVKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILG 1970
            ||.|||.|||:||||  ||   :.:.:|.::||:|:::.|:|..|:|.|..|:|.:.|.||||||
Human   607 AFSVAYQEFLRANGINPED---LSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILG 668

  Fly  1971 VVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGLSLVGLPLSTCQTYIKNTKNQT 2035
            ||||||||||:||||:|||:|..|.|.:.|:||||||:::|||.|||||||||||:.||..|||:
Human   669 VVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQS 733

  Fly  2036 VVKFTVVPCAPVVEVKIKRPETKYQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVA 2100
            .||..:|.|.||..|.|:||:.:||||||||||:||||:||||||||||||||||||||.|||||
Human   734 RVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVA 798

  Fly  2101 VPHEKIVNLLATSVGEILMKTMPTSMFRLLTGQENPIYI 2139
            .||||||::|:.:||||.|||||.:|:||||.||.|:||
Human   799 TPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919	105/182 (58%)
		PDZ_signaling	1957..2042	CDD:238492	57/84 (68%)
		PDZ_signaling	2047..2120	CDD:238492	55/72 (76%)
APBA1	NP_001154.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93
		Munc-18-1 binding	226..314		17/104 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..342		22/135 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..435		19/132 (14%)
		LIN-2/CASK binding	373..436		15/94 (16%)
		PTB_X11	452..623	CDD:269919	104/171 (61%)
		Autoinhibitory helix linker. /evidence=ECO:0000250	626..641		4/14 (29%)
		PDZ	656..739	CDD:278991	56/82 (68%)
		PDZ_signaling	745..818	CDD:238492	55/72 (76%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155499
Domainoid	1	1.000	172	1.000	Domainoid score	I3726
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3496
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8492
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	LDO	PTHR12345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2607
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.680