DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11Lbeta and Apba1

DIOPT Version :9

Sequence 1:	NP_727440.3	Gene:	X11Lbeta / 31997	FlyBaseID:	FBgn0052677	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	NP_796008.2	Gene:	Apba1 / 319924	MGIID:	1860297	Length:	842	Species:	Mus musculus

Alignment Length:	948	Identity:	339/948 - (35%)
Similarity:	459/948 - (48%)	Gaps:	252/948 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1325 DQSPSNHSKVFKNIDPELDSLYSIGVFHRPDTV---QMTPPPPAPAPHRKPNNNGCSSGVVNTNG 1386
            |::|.  .:|.::::.:|:         .|:.|   |.:|.||.||.|...::.|
Mouse    14 DEAPG--GEVNESVEADLE---------HPEVVEGQQPSPSPPPPAGHEPEDHRG---------- 57

  Fly  1387 SLAGGSNDVDLLQPSSKHTP-------------LAAAISSTLQRSSPTSTITGNGIG---NGSGK 1435
                        .|:....|             ||.:.|:.....:.|.|..|:.:.   :|...
Mouse    58 ------------HPAPPPPPPPQEEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEA 110

  Fly  1436 TRSAGSNCSSSANGGMPPPIPERTNL-----VSAVQRSPSPGPNSPVWLSRHLDGGAGKDLLESG 1495
            .|:..::..|:......|...|.|..     |.|.||...|
Mouse   111 ERAQDADDESAYAVQYRPEAEEYTEQAEAEHVEAAQRRALP------------------------ 151

  Fly  1496 SDNHSKNHSADEEDVDTDLETDRLLGHQ---RLDDQGYYDENKSWDRKPRSLLSKISPKQQIPST 1557
              ||...||.:.|:......:..:..|:   |.:|:.|.:....:......:..:|.   ..|..
Mouse   152 --NHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIG---DAPEL 211

  Fly  1558 KTRNG------------------YNALL----------SSTPELPPPIPPKGQSGLGLGLTLGAG 1594
            :.|:|                  ..|.|          |.:||......|..:        :.:.
Mouse   212 EARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPR--------MDSY 268

  Fly  1595 NGGKLLDLVGGMVQRSLSRSSSE-------HSEKSLSKMPISGGDLCAGGVDVVASTVAATSATV 1652
            ...:.:|.:...|::|:|..|.:       .:|:.|.:.|..||    |..|.......|.....
Mouse   269 EQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGG----GHPDSPGLPAPAGQQQR 329

  Fly  1653 VASTPALGSPGNGGGSE---------RSAAEMA-----------------------NPGGAVKLS 1685
            |..||        ||||         |.|..:|                       .|...:.:.
Mouse   330 VVGTP--------GGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVM 386

  Fly  1686 EQEIG---------TINGGSVMPLGSGSGTGSGAGS-GAGSGTGTNAAVVANSNANNNVGGGGGG 1740
            .|:|.         .::|.|..| ||.|..|:.:.| ....|..|.|
Mouse   387 RQDISPTRDCDDQRPVDGDSPSP-GSSSPLGAESSSIPLHPGDPTEA------------------ 432

  Fly  1741 GNNSSGSGAGSNSNSGEKKVKKSKSKEGGAV----------LIEGVLFRAKYLGSTQLVCEGQPT 1795
                          |..|:.:||.:.....|          ||:|::|.|.|||||||:.:..|:
Mouse   433 --------------STNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPS 483

  Fly  1796 KSTRMMQAEEAVSRIKAL---------APDGDVQPSTEVDLFISTEKIMVLNTDLKEIMMDHALR 1851
            |:.|||||:|||||||..         ||:|:.||.|||||||||::|.|||.|.:|.||||.||
Mouse   484 KNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLR 548

  Fly  1852 TISYIADIGDLVVLMARRRFVP----QDIDDAPKPN----RTPKMICHVFESDEAQFIAQSIGQA 1908
            |||||||||::|||||||| :|    |:..:|..|:    |..|||||||||::||.||||||||
Mouse   549 TISYIADIGNIVVLMARRR-MPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQA 612

  Fly  1909 FQVAYMEFLKANGI--EDHRFVKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGV 1971
            |.|||.|||:||||  ||   :.:.:|.::||:|:::.|:|..|:|.|..|:|.:.|.|||||||
Mouse   613 FSVAYQEFLRANGINPED---LSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGV 674

  Fly  1972 VIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGLSLVGLPLSTCQTYIKNTKNQTV 2036
            |||||||||:||||:|||:|..|.|.:.|:||||||:::|||.|||||||||||:.||..|||:.
Mouse   675 VIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSR 739

  Fly  2037 VKFTVVPCAPVVEVKIKRPETKYQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAV 2101
            ||..:|.|.||..|.|:||:.:||||||||||:||||:||||||||||||||||||||.|||||.
Mouse   740 VKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVAT 804

  Fly  2102 PHEKIVNLLATSVGEILMKTMPTSMFRLLTGQENPIYI 2139
            ||||||::|:.:||||.|||||.:|:||||.||.|:||
Mouse   805 PHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919	105/182 (58%)
		PDZ_signaling	1957..2042	CDD:238492	57/84 (68%)
		PDZ_signaling	2047..2120	CDD:238492	55/72 (76%)
Apba1	NP_796008.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..121		24/139 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..349		25/130 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	366..439		16/105 (15%)
		PTB_X11	457..628	CDD:269919	104/171 (61%)
		Autoinhibitory helix linker. /evidence=ECO:0000250	631..648		4/16 (25%)
		PDZ	661..744	CDD:366185	56/82 (68%)
		PDZ_signaling	750..823	CDD:238492	55/72 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845952
Domainoid	1	1.000	172	1.000	Domainoid score	I3706
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3496
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8726
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	LDO	PTHR12345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2607
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.680