DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11Lbeta and SDCBP2

DIOPT Version :9

Sequence 1:	NP_727440.3	Gene:	X11Lbeta / 31997	FlyBaseID:	FBgn0052677	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	NP_001186713.1	Gene:	SDCBP2 / 27111	HGNCID:	15756	Length:	292	Species:	Homo sapiens

Alignment Length:	154	Identity:	36/154 - (23%)
Similarity:	71/154 - (46%)	Gaps:	2/154 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly  1986 VIANLMSSGAAARCGQLNIGDQLIAINGLSLVGLPLSTCQTYIKNTKNQTVVKFTVVPCAPVVEV 2050
            :...|:.:...|....|..||||:.|:|....|.........:|......:|  .||...|....
Human   130 LFVQLVQANTPASLVGLRFGDQLLQIDGRDCAGWSSHKAHQVVKKASGDKIV--VVVRDRPFQRT 192

  Fly  2051 KIKRPETKYQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVNLLATSVG 2115
            .....::...:||.::.|.|.||::|..|.|.|:...|.:.|::.|:|:.:..:||:.:|||:..
Human   193 VTMHKDSMGHVGFVIKKGKIVSLVKGSSAARNGLLTNHYVCEVDGQNVIGLKDKKIMEILATAGN 257

  Fly  2116 EILMKTMPTSMFRLLTGQENPIYI 2139
            .:.:..:|:.::..:..:..|:.:
Human   258 VVTLTIIPSVIYEHMVKKLPPVLL 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919
		PDZ_signaling	1957..2042	CDD:238492	12/55 (22%)
		PDZ_signaling	2047..2120	CDD:238492	19/72 (26%)
SDCBP2	NP_001186713.1	PDZ	117..185	CDD:238080	13/56 (23%)
SDCBP2	NP_001186713.1	PDZ_signaling	191..264	CDD:238492	19/72 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155500
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840