DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11Lbeta and lin-10

DIOPT Version :9

Sequence 1:	NP_727440.3	Gene:	X11Lbeta / 31997	FlyBaseID:	FBgn0052677	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	NP_492226.2	Gene:	lin-10 / 172597	WormBaseID:	WBGene00002999	Length:	982	Species:	Caenorhabditis elegans

Alignment Length:	1485	Identity:	446/1485 - (30%)
Similarity:	590/1485 - (39%)	Gaps:	560/1485 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 AAAASAAADESEP-------PAAAEGAAAATATSQPQQQVPMATVPPLSSTATSLQKTAARAALA 761
            |.||:.:.:...|       |..::|..|.......|||||...:||
Worm     9 ATAATTSPEHGVPTSSATPTPPPSKGGGAGGGGGGEQQQVPFQMIPP------------------ 55

  Fly   762 ALAQSHPHSSHNILSTLL-PHSPNPVNPGQMHAAQQSIQNYPVRPGFPQRIISPPSRDPRSSSPP 825
                     .|...:..| |:.|....|.|...||            ||.:.||
Worm    56 ---------GHFFANPFLNPYIPTAGAPAQEGEAQ------------PQMVFSP----------- 88

  Fly   826 LQQQQYQQQQQQQLQHQQQHFASLMSSHSNNNSNTNKQPLSSDNNAEDTSNDVSEIGTISDLTTP 890
                    .|.|::.|  .:|..:|:
Worm    89 --------AQYQEVMH--HYFQQMMA--------------------------------------- 104

  Fly   891 EAVGLSIGIAAGEMASRASTP--------PQTAQAPPTAVAGSTANGTGSGNGTATGNATAAGSG 947
                          ||.|..|        |...|..|::.| |:::.:...||..|..:..: |.
Worm   105 --------------ASGAQFPIPFPMQFQPALQQPRPSSQA-SSSHRSEDDNGRQTAGSVVS-SN 153

  Fly   948 LGPLSLHTKSSTFDYLYEFSETRKVLEEFFKCPSTDEQPI-MENGSDVDSIDIQYEFHSNFERDE 1011
            :.|.....:.:.     :.:||..|::      :.||..: ....|||...|: .|...:.|..:
Worm   154 VSPNHREVRPAE-----DSTETSGVVQ------NNDELLVPTSTSSDVTIGDV-IEKSDSPENSQ 206

  Fly  1012 EDLAEEEEAEDDEEVDDDADE---ENDEAEDEDEPLEQDRDQNYRAQAPPQSGHIDSERLVYSGY 1073
            |....||::|:..::..|..:   ....:|.|.|...:.:::|.:.        ||.:.|
Worm   207 ESAGGEEKSEEKRKLSGDRTDSLIRKQMSEMEKEITRRSQNKNIKT--------IDDDGL----- 258

  Fly  1074 GQQPQLQAQLTAQPMSGARRHYSGSPLMRDFDFFLDSTSRS-------SGERDADQDGLNHNQLL 1131
                       |:.:.|:    |...:..||..|:|.:..|       |.|:.|.::.|  |||.
Worm   259 -----------AELIGGS----STRTVADDFSPFVDKSGLSYTAPAPPSTEKSAPKESL--NQLR 306

  Fly  1132 STSSGHGGGVGVSGGLGVGPGGGHNYRYSPETTDYDSNCGDLDSLSGEMNGGVSTSCSNYAKFYA 1196
            |:.:      .......|||.|       |.|....|          :.....|...:|...|..
Worm   307 SSFN------LPDDSTTVGPVG-------PSTVPQQS----------QQFANNSMFMANAGNFVQ 348

  Fly  1197 SAMPV---LEDGLSSGHTSDTENNNNNQKNLQQSTVNQGGQCPTSLSGSTSIGGSGGISMLMDMK 1258
            :|.|:   :....:.|.....:....:|.||.....|     ||.::..|:             .
Worm   349 NAFPIGVTMTPQATFGAAPGFQMMQPHQHNLFMQQPN-----PTFVNNGTN-------------P 395

  Fly  1259 RISTNHSL-NSMNNQTTTASTTTDSNGGVGGVGHHLVATLVASPNNEQ-AKSQCQTQLQSHPPKT 1321
            .:.|..:| |.:.|.|.....|..:.       ......|.|:...:| |:|...|...|.||..
Worm   396 FLQTQATLPNFVQNGTAPLVPTVSAQ-------QFTPEQLAAAFAQQQIAQSAAPTPFDSPPPSM 453

  Fly  1322 LSLDQSPSNHSKVFKNIDPELDSLYSIGVFHRPDTVQMTPPPPAPAPHRKPNNNGCSSGVVNTNG 1386
            .|....||.                           .:.||||
Worm   454 PSTSSGPSG---------------------------ALAPPPP---------------------- 469

  Fly  1387 SLAGGSNDVDLLQPSSKHTPLAAAISSTLQRSSPTSTITGNGIGNGSGKTRSAGSNCSSSANGGM 1451
                         ||.   |:...:|                 |||..:........:|:.||..
Worm   470 -------------PSH---PIPRRVS-----------------GNGWPEENKENGTSTSTTNGAQ 501

  Fly  1452 PPPIPERTNLVSAVQRSPSPGPNSPVWLSRHLDGGAGKDLLESGSDNHSKNHSADEEDVDTDLET 1516
            ..|              .:.|.:.|||:.|               |::.|
Worm   502 SVP--------------AAAGTDDPVWVLR---------------DSYLK--------------- 522

  Fly  1517 DRLLGHQRLDDQGYYDENKSWDRKPRSLLSKISPKQQIPSTKTRNGYNALLSSTPELPPPIPPKG 1581
             ::...||..:    :|..||..
Worm   523 -KMQREQRTSE----EEEMSWQE------------------------------------------ 540

  Fly  1582 QSGLGLGLTLGAGNGGKLLDLVGGMVQRSLSRSSSEHSEKSLSKMPISGGDLCAGGVDVVASTVA 1646
                                                                            |
Worm   541 ----------------------------------------------------------------A 541

  Fly  1647 ATSATVVASTPALGSPGNGGGSERSAAEMANPGGAVKLSEQEIG-TINGGSVMPLGSGSGTGSGA 1710
            ||:|...|.        ||||.::              .|||.. .:|||:
Worm   542 ATAAQEAAE--------NGGGDDQ--------------EEQETDRLLNGGT-------------- 570

  Fly  1711 GSGAGSGTGTNAAVVANSNANNNVGGGGGGGNNSSGSGAGSNSNSGEKKVKKSKSKEGGAVLIEG 1775
                   ||                        :|..||....:..:||..|.......||||||
Worm   571 -------TG------------------------ASTKGAERRGSVDKKKNSKETMVHEPAVLIEG 604

  Fly  1776 VLFRAKYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPDGDVQPSTEVDLFISTEKIMVLNTD 1840
            |||||:||||||::||.:.:|:.||.||:|||:|:|  ||:||||||||:|||||||||||||||
Worm   605 VLFRARYLGSTQMLCESRGSKAARMAQAQEAVARVK--APEGDVQPSTEIDLFISTEKIMVLNTD 667

  Fly  1841 L---------KEIMMDHALRTISYIADIGDLVVLMARRRFVPQDIDDAPKPN-------RTPKMI 1889
            |         ::|:||||||||||||||||||||||||.......:.....:       :|||:|
Worm   668 LQRISDTDVRQDILMDHALRTISYIADIGDLVVLMARRMSTSHSDESCSDGDSSGGGVRKTPKVI 732

  Fly  1890 CHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIEDHRFVKEMDYQEVLNSQEIFGDELEIFAKKE 1954
            |||||||||.||||||||||||||:|||:||||:|..:::::||||||||||:.|||||:|||||
Worm   733 CHVFESDEASFIAQSIGQAFQVAYVEFLRANGIDDPSYLRQIDYQEVLNSQELLGDELEMFAKKE 797

  Fly  1955 LQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGLSLVGL 2019
            .||||||||..||.||:|:|||||||||||||:|::...|.||...:||||||:|.|||:|||||
Worm   798 TQKEVVVPKKAGEPLGIVVVESGWGSMLPTVVLAHMNPVGPAAHSNKLNIGDQIININGISLVGL 862

  Fly  2020 PLSTCQTYIKNTKNQTVVKFTVVPCAPVVEVKIKRPETKYQLGFSVQNGVICSLLRGGIAERGGV 2084
            |||..||.|||.|..|.|:.|||...|||||:|:||:|||||||||||||||||||||||||||:
Worm   863 PLSAAQTQIKNMKTATAVRMTVVSTPPVVEVRIRRPDTKYQLGFSVQNGVICSLLRGGIAERGGI 927

  Fly  2085 RVGHRIIEINNQSVVAVPHEKIVNLLATSVGEILMKTMPTSMFRLLTGQENPIYI 2139
            ||||||||||..|||||.|::|||:|||:||||.||||||||||||||||.|.||
Worm   928 RVGHRIIEINGTSVVAVAHDRIVNMLATAVGEIHMKTMPTSMFRLLTGQEQPQYI 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919	114/169 (67%)
		PDZ_signaling	1957..2042	CDD:238492	56/84 (67%)
		PDZ_signaling	2047..2120	CDD:238492	60/72 (83%)
lin-10	NP_492226.2	PTB_X11	598..767	CDD:269919	114/170 (67%)
		PDZ_signaling	800..885	CDD:238492	56/84 (67%)
		PDZ_signaling	890..963	CDD:238492	60/72 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161287
Domainoid	1	1.000	190	1.000	Domainoid score	I1922
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	519	1.000	Inparanoid score	I689
Isobase	1	0.950	-	0	Normalized mean entropy	S3496
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002645
OrthoInspector	1	1.000	-	-		otm14765
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	LDO	PTHR12345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2607
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.870