DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11Lbeta and apba2a

DIOPT Version :9

Sequence 1:	NP_727440.3	Gene:	X11Lbeta / 31997	FlyBaseID:	FBgn0052677	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	XP_021326395.1	Gene:	apba2a / 100330365	ZFINID:	ZDB-GENE-121107-1	Length:	923	Species:	Danio rerio

Alignment Length:	1061	Identity:	341/1061 - (32%)
Similarity:	499/1061 - (47%)	Gaps:	218/1061 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1157 YRYSPETTDYDSNCGDLDSLSGEMNGGVSTSCSNYAKFYASAMPVLEDGLSSGHTSD--TENNNN 1219
            ::..|||.          |::.|:|...           .||:|...:.| ||...|  .|...:
Zfish     3 FKRRPETR----------SVAAELNPPA-----------FSAVPEGREQL-SGDRDDPVLEEAEH 45

  Fly  1220 NQKNLQQSTVNQGGQCPTSLSGSTSIGGSGGISM-LMDMKRISTNHSLNSMNNQ----------- 1272
            ::.:.|..:........:..||..||.|...:.. .|:...:|...::.|.:.|
Zfish    46 DKLDCQTPSPTPAQYSLSDESGDDSIRGESPLQPDSMEEDSLSEYDNVGSGDEQEEVERDYEEDE 110

  Fly  1273 --TTTASTTT-------DSNGGVGGVGHHLVATLVASPNNEQ-AKSQCQ-TQLQSHPPKTLSLDQ 1326
              .|.|...|       :....:.|:..|..|.....|:..| .:..|: .:...|...:|...|
Zfish   111 ELQTEADRMTYYVHCCPEDESYMEGLDCHEGADGAECPSTSQDVRESCKPKEAWEHSDTSLCKGQ 175

  Fly  1327 SPSNHSKVFKNIDPELDSLYSIGVFHRPDTVQMTPPPPAPAPHRKPNNNGCSSGVVNTNGSLAGG 1391
            .....:.|:|..:|..::.:........:..:............:..:||   |..:..|
Zfish   176 QKDAATMVYKQPEPITETTFVQAPMAEDEEDEEETEEDVEEEDSEEEDNG---GFFHYEG----- 232

  Fly  1392 SNDVDLLQPSSKHTPLAAAISSTLQR--SSPTSTITGNGIGNGSGKTRS---------AGSNCSS 1445
             |:.:|   ::...|.....|:..:|  .||....:...:|..|.:::.         .||||:
Zfish   233 -NEAEL---NNNEIPHKDNCSNVCRREGKSPPQEFSRVKVGQESRRSQDNPKYSRDVPLGSNCT- 292

  Fly  1446 SANGGMPPPIPERTNLVSAVQRSPSPGP---NSPV-------------WLSRHLDGGAGKDLLES 1494
                       :|..:.....::.|..|   |:||             :...||:   .|:..|:
Zfish   293 -----------QRDRMERVRDKNGSDCPKVSNAPVARESRKDSRQNFKYRGHHLE---TKNNRET 343

  Fly  1495 GSDNHS----KNHSADEEDVDTDLETDRLLGHQRLDDQGYYDENKSWDRKPRSLLSKISPKQQIP 1555
            ....||    |..|||.||..| .:...||.:.|.|.:| .|.|.|..|.......|..|:....
Zfish   344 AYQGHSAVTIKGKSADAEDRGT-WKKRHLLKYSREDARG-GDGNNSHKRSKSPENCKNRPQDHPI 406

  Fly  1556 STKTRNGYNALLSSTPELPPPIPPKGQSGLGLGLTLGAGNGGKL------LDLVGGMVQ--RSLS 1612
            .:...||.|     ..::...:..:.::.:...|.:...|.|:.      ...|.|..:  |:.|
Zfish   407 CSHKSNGEN-----ERKISGNVEARIENEVKTKLIIAPNNSGRTKVAPDQAKNVKGAPESPRASS 466

  Fly  1613 RSSSEHSEKSLSKMPISGGDLCAGGVDVVASTVAATSATVVASTPALGSPGNGGGSERSAAEMAN 1677
            .||.:.:.|...:                            |:||.           :|.|:..|
Zfish   467 ASSGKRNSKPRGQ----------------------------ANTPV-----------QSPAKQVN 492

  Fly  1678 PGGAVKLSEQEIGTINGGSVMPLGSGSGTGSGAGSGAGSGTGTNAAVVANSNANNNVGGGGGGGN 1742
            ...|..:.|::                             |..|...|:.|.:.          :
Zfish   493 KDSAKPVEEEK-----------------------------TRPNEEQVSQSASQ----------D 518

  Fly  1743 NSSGSGAGSNSNSGEKK--------VKKSKSKEGGAVLIEGVLFRAKYLGSTQLVCEGQPTKSTR 1799
            :|:|..:|.|....::.        :......|.   ||.|::|.|.|||||||:.:..|:||.|
Zfish   519 SSTGPPSGQNRPQTQRNPSFPSFVDIPGPCEPED---LINGIIFAANYLGSTQLLSDRNPSKSVR 580

  Fly  1800 MMQAEEAVSRIKALAPDGDVQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVV 1864
            |.||:|||..:||:  :.:.|..||:||||||:.|.|||.|.:|.|||:||||||||||||::||
Zfish   581 MKQAQEAVDCVKAV--EVETQSLTEIDLFISTKAIKVLNADTQETMMDNALRTISYIADIGNVVV 643

  Fly  1865 LMARRRFVPQDID------DAPKPNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIE 1923
            ||||||.....:|      ::...::..:|||:||||::||.|||||||||.:||.|||:||||
Zfish   644 LMARRRLSNSSLDCTESGLNSDANHKQYRMICYVFESEDAQLIAQSIGQAFSMAYQEFLRANGI- 707

  Fly  1924 DHRFVKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIA 1988
            :.:.:.:.||.::||:||::.|:|..|:..:..|::.:.|.||||||||||||||||:||||::|
Zfish   708 NPKDLSQKDYSDILNTQEMYNDDLVHFSNSDNCKQLHLEKQKGEILGVVIVESGWGSILPTVILA 772

  Fly  1989 NLMSSGAAARCGQLNIGDQLIAINGLSLVGLPLSTCQTYIKNTKNQTVVKFTVVPCAPVVEVKIK 2053
            .::::|.|||.|:||:|||::|:|..|||||||:.||..||..||...||.:||.|.||..|.||
Zfish   773 CMLNNGPAARSGKLNVGDQIMAVNDTSLVGLPLAACQGIIKALKNHVQVKLSVVSCPPVTTVLIK 837

  Fly  2054 RPETKYQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVNLLATSVGEIL 2118
            ||:.:||||||||||:||||:||||||||||||||||||||.|||||:.|||||:.|:.|||||.
Zfish   838 RPDLQYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVAMAHEKIVHALSVSVGEIN 902

  Fly  2119 MKTMPTSMFRLLTGQENPIYI 2139
            |||||..|||||||||.|:|:
Zfish   903 MKTMPAVMFRLLTGQETPVYM 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919	90/159 (57%)
		PDZ_signaling	1957..2042	CDD:238492	50/84 (60%)
		PDZ_signaling	2047..2120	CDD:238492	56/72 (78%)
apba2a	XP_021326395.1	CBF	<21..114	CDD:332044	18/93 (19%)
		PTB_X11	550..709	CDD:269919	91/164 (55%)
		PDZ	742..823	CDD:278991	48/80 (60%)
		PDZ_signaling	831..904	CDD:238492	56/72 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590661
Domainoid	1	1.000	175	1.000	Domainoid score	I3583
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1184
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6563
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	O	PTHR12345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.790