Protein Alignment X11Lbeta and apba1a

DIOPT Version :9

• Sequence 1: NP_727440.3
• Gene: X11Lbeta / 31997
• FlyBaseID: FBgn0052677
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: XP_001343372.1
• Gene: apba1a / 100003938
• ZFINID: ZDB-GENE-060526-175
• Length: 968
• Species: Danio rerio
• Alignment Length: 1173
• Identity: 378/1173 - (32%)
• Similarity: 514/1173 - (43%)
• Gaps: 338/1173 - (28%)

  Fly  1074 GQQPQLQAQLTAQPMSGARRHYSGSPLMRDFDFFLDSTSRSSGERDADQDGLNHNQLLSTSSGHG 1138
            ||||         |.|..|||.:|           |.:|||:..|:...:. ||:|     |.|
Zfish    27 GQQP---------PSSHRRRHNNG-----------DGSSRSNRSRNHGTEN-NHHQ-----SQH- 64

  Fly  1139 GGVGVSGGLGVGPGGGHNYRYSPETTDYDSNCGDLDSLSGEMNGGVSTSCSNYAKFYASAMPVLE 1203
                         .|...||          .|      .|. |||.:       :.:|:..|. |
Zfish    65 -------------QGAPRYR----------RC------EGS-NGGTN-------RTHAARRPE-E 91

  Fly  1204 DGLSSGHTSDTENNNNNQKNLQQSTVNQGGQCPTSLSGSTSIGGSGGISMLMDMKRISTNHSLNS 1268
            :|                 :.:|.|:.|    |......|.....|.     :..|:........
Zfish    92 EG-----------------DAEQQTIQQ----PIPRPAVTRYRRQGD-----NEARLRAQQQRQR 130

  Fly  1269 MNNQTTTASTTTDSNGGVGGVGHHLVATLVASPNNEQAKSQCQTQLQSHPPK---------TLSL 1324
            ...:....:...:.        |.|       ...:|..|..||.|.:..|:         :.:|
Zfish   131 QRERQQRDAERAEQ--------HRL-------EQQQQLLSPTQTMLPTREPEEAEEDEGDGSSAL 180

  Fly  1325 DQSPSNHSKVFKNID-------------PELDSLYSIGVFHRPDTVQMT---------------- 1360
            .:|.|..|....:.|             ||.::.|.|.:  ||:..:.|
Zfish   181 ARSASTESGFHNHTDRAEGDAVMVLEAEPEDENTYGIPL--RPEAEEYTESAESEQQHGGPAYLQ 243

  Fly  1361 ---PPPPAPAPHRKPNNNG---CSSGVVNTNGSL-------------------AGGSNDVDLLQP 1400
               ||.|.|.| |:|..|.   ..:..:|.|.|.                   .|.:.|....:|
Zfish   244 PQYPPQPPPLP-REPLPNAERPLEAETLNPNYSSYVYTQPMYHNPTEAGEAHEGGATEDEQYSEP 307

  Fly  1401 SSKHT------------PLAAAISSTLQRSSPTSTITGNGIGNGSGKTRSAGSNCSSSANGGMPP 1453
            ...:|            ||:.|...|.|:..|...:....:........|...:....::|....
Zfish   308 YVDYTLQEHVYEEITDAPLSRAEGQTPQQQRPEFRLFERDLYQQQEAVGSRLHHYDERSDGESDS 372

  Fly  1454 PIPERTNLVSAVQRSPSPGPNSPVWLSRHLDGGAGKDLLESGSDNHSKNHSADEEDVDTDL-ETD 1517
            |..|       .:.:|.|..:|                            ...:||:|..: |..
Zfish   373 PEKE-------AEFAPYPRADS----------------------------CEQDEDIDQIVAEVK 402

  Fly  1518 RLLGHQRLD-------DQGYYDENKSW-DRKPRSLLSKISPKQQIPSTKTRNGYNALLSSTPELP 1574
            ..|..|.||       ..|  |:.:.| :.:....|:..:|.:.:              |..|||
Zfish   403 ESLSSQSLDRIAMGLNKDG--DKEEDWPESESHGQLNDNNPLEPV--------------SEGELP 451

  Fly  1575 PPIPPKGQSGLGLGLTLGAGNGGKLLDLVGGMVQRSLSRSSSEHSEKSLSKMPISGGDLCAGGVD 1639
            .. |.:.|:                          .:.|||.|  ::....:.|.         |
Zfish   452 RS-PSEDQA--------------------------PVIRSSRE--KRDAISLAIK---------D 478

  Fly  1640 VVASTVAATSATVVASTPALGSPGNGGGSERSAAEMANPGGAVKLSEQEIGTINGGSVMP-LGSG 1703
            :..:.....:.||                 ||......|...:.:..|::.......:.| ||:.
Zfish   479 IKEAIEEVKTRTV-----------------RSPYTPDEPKEPIWVMRQDLSPTAESDLQPSLGAD 526

  Fly  1704 S-GTGSGAGSGAGSGTGTNAAVVANSNANNNVGGGGGGGNNSSGSGAGSNSNSGEKKVKKSKSKE 1767
            | |:||.:..||.|             :::.:....|..:..|.|.||..|..............
Zfish   527 SPGSGSTSPQGAES-------------SSHQMMSQEGSDSFESPSPAGKESRRSLASFPTYVEVP 578

  Fly  1768 GGA---VLIEGVLFRAKYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKAL---------APDGDVQ 1820
            |..   .||:|::|.|.|||||||:.:..|:|:.|||||:|||||||..         ||:||.|
Zfish   579 GPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKNKKKAPEGDAQ 643

  Fly  1821 PSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPQD-------IDD 1878
            |.|||||||||::|.|||.|.:|.||||.|||||||||||::||||||||....|       .|.
Zfish   644 PMTEVDLFISTQRIKVLNADSQETMMDHPLRTISYIADIGNIVVLMARRRMPRSDSQENMEASDP 708

  Fly  1879 APKPNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGI--EDHRFVKEMDYQEVLNSQE 1941
            |....|..|||||||||::||.|||||||||.|||.|||:||||  ||   :.:.:|.::||:|:
Zfish   709 AQDEKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPED---LSQKEYSDLLNTQD 770

  Fly  1942 IFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGD 2006
            ::.|:|..|:|.|..|:|.:.|.||||||:|||||||||:||||:|||:|..|.|.:.|:|||||
Zfish   771 MYNDDLIHFSKSENCKDVYIEKQKGEILGLVIVESGWGSILPTVIIANMMHGGPAEKSGRLNIGD 835

  Fly  2007 QLIAINGLSLVGLPLSTCQTYIKNTKNQTVVKFTVVPCAPVVEVKIKRPETKYQLGFSVQNGVIC 2071
            |:::|||.|||||||||||:.||..|||:.:|..:|.|.||..|.|:||:.:||||||||||:||
Zfish   836 QIMSINGTSLVGLPLSTCQSIIKGLKNQSRIKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIIC 900

  Fly  2072 SLLRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVNLLATSVGEILMKTMPTSMFRLLTGQENP 2136
            ||:||||||||||||||||||||:|||||.||||||::|:.:||||.|||||.:|:||||.||.|
Zfish   901 SLMRGGIAERGGVRVGHRIIEINSQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQP 965

  Fly  2137 IYI 2139
            :||
Zfish   966 VYI 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919	104/174 (60%)
		PDZ_signaling	1957..2042	CDD:238492	55/84 (65%)
		PDZ_signaling	2047..2120	CDD:238492	55/72 (76%)
apba1a	XP_001343372.1	PTB_X11	583..754	CDD:269919	104/170 (61%)
		PDZ	787..870	CDD:278991	54/82 (66%)
		PDZ_signaling	876..949	CDD:238492	55/72 (76%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590663
Domainoid	1	1.000	175	1.000	Domainoid score	I3583
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1184
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6563
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	LDO	PTHR12345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.890