DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and NPEPPS

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_016880861.1	Gene:	NPEPPS / 9520	HGNCID:	7900	Length:	924	Species:	Homo sapiens

Alignment Length:	954	Identity:	239/954 - (25%)
Similarity:	392/954 - (41%)	Gaps:	156/954 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQP------FGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVT 83
            |||..:.|::|.:.:        :|      |.|.:....:..::|.:||:|..|:.|     :|
Human    53 RLPADVSPINYSLCL--------KPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDI-----IT 104

  Fly    84 LS--DKNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHN 146
            .|  .:....:..:......:..::|:|....|:.. |.::::.|...|.:...|||.|.|...:
Human   105 ASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTG-TGTLKIDFVGELNDKMKGFYRSKYTTPS 168

  Fly   147 TTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVW 211
            ..: ::.|.||||...||.||||:|:|..:..|.|:|..|....|||||.|.....:...::.|.
Human   169 GEV-RYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVE 232

  Fly   212 TQFVESHPMQTYLVAFMISKFDRPGFTSSERSD--CPISTWARPDALSQTEFANMVVAPLLSFYE 274
            .:|..:..|.||||||::.::|   |..:...|  | :..:.......|.:||..|.|..|.||:
Human   233 VKFARTPVMSTYLVAFVVGEYD---FVETRSKDGVC-VRVYTPVGKAEQGKFALEVAAKTLPFYK 293

  Fly   275 DLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQW 339
            |.||..|...||||:|:.||...:.|||||..:.|.:||.|.:.|....:|.||..|...:.:||
Human   294 DYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQW 358

  Fly   340 FGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASV 404
            |||||::.||..:||...||.::....|....||:|...:.....|....:.||..|:..:..||
Human   359 FGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSV 423

  Fly   405 PDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDR 469
            ...|.:...::.|...|.|.:..|||..:|::.:...:..||..:..:.|.:.|.|:.|:
Human   424 GHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLE----- 483

  Fly   470 NGRLGKGLNITRIMKCWLGQPGYPLVTVTRNY--DHRTAIVSQQRFFITPQFRNRWARNPCWWVP 532
               ...|..|..:|..|..|.|:||:.|....  |.|...:||::|.....:.....  |.|.||
Human   484 ---NASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDC--PQWMVP 543

  Fly   533 LSYTCPSCQHSEIISFSRWLTCPTSK-PSSKSNTVLLEKLE-------AEPTDWILFNVQHTAPF 589
                               :|..||: |:.....:|::|.|       .:|..|:..|:.....:
Human   544 -------------------ITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFY 589

  Fly   590 RVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFV 654
            |..|.....:.|...:.|.:    :..|:|..|.:||||||.:|.|.....|.::....:|..:.
Human   590 RTQYSSAMLESLLPGIRDLS----LPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYT 650

  Fly   655 VW---------VATEIS----FERINNVAKSNPNYLIFKTYMRLL----------LERQFKRVIS 696
            ||         ::|.:|    :|.|....|.     :|......|          |:...:.::.
Human   651 VWSDLSCNLGILSTLLSHTDFYEEIQEFVKD-----VFSPIGERLGWDPKPGEGHLDALLRGLVL 710

  Fly   697 SDLTSSSGNMTHRPVIIRLACEYELPACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKFGTE 761
            ..|    |...|:             |.:..|||.| |...|....::...|..|..|.:|.|..
Human   711 GKL----GKAGHK-------------ATLEEARRRF-KDHVEGKQILSADLRSPVYLTVLKHGDG 757

  Fly   762 GDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSM 826
            ...|::..::|:::...||..:...|..:.....:|:||.:.. |..||.|:.......|...|.
Human   758 TTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFAL-SEEVRPQDTVSVIGGVAGGSK 821

  Fly   827 -GYRLAKKYVSVNMQNIRN-----YCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMN 885
             |.:.|.|::..|.:.:.|     :..:...| |..:||:|..|           :..|:.|..
Human   822 HGRKAAWKFIKDNWEELYNRYQGGFLISRLIK-VQWLTPVIPAL-----------WDAEVGRSP- 873

  Fly   886 GSERLIKILLERGNDNIHWQRTKFRPMLQAIRD--IILWRSRAK 927
                      |.|:..:.|      |....:||  :|.|..|.:
Human   874 ----------EVGSSRLSW------PTCYQLRDLQLIKWLERLR 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	121/405 (30%)
		M1_APN_2	33..493	CDD:189008	135/469 (29%)
		ERAP1_C	579..897	CDD:288671	70/346 (20%)
NPEPPS	XP_016880861.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820