Protein Alignment CG2111 and AAP1

DIOPT Version :10

• Sequence 1: NP_572644.1
• Gene: CG2111 / 31995
• FlyBaseID: FBgn0030223
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 945
• Identity: 230/945 - (24%)
• Similarity: 385/945 - (40%)
• Gaps: 210/945 - (22%)

  Fly    26 LPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNGN 90
            ||..:.||.|  ||....|.....|.|::.|||:         :|.|.:               |
Yeast     6 LPNNVTPLHY--DITLEPNFRAFTFEGSLKIDLQ---------INDHSI---------------N 44

  Fly    91 SVPVSSIQMDIKLSRL---------------TVSLKRPLKVNVTY-------SMRVAFTSVLRND 133
            ||.::.:::|...:|:               ..:|..|   |.|:       .:.:.|:.:|.:.
Yeast    45 SVQINYLEIDFHSARIEGVNAIEVNKNENQQKATLVFP---NGTFENLGPSAKLEIIFSGILNDQ 106

  Fly   134 NTGFYSSNYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQ 198
            ..|||.:.|.|..|..|:::|.||.|...||.||||||:|..:..|.:.|........||||.|:
Yeast   107 MAGFYRAKYTDKVTGETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVR 171

  Fly   199 -RTIRHASLKDYVWTQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFA 262
             .||:..  |.|  |.|..:..|.||||||:::..   .:..|.....|:..::.|......:||
Yeast   172 NETIKEG--KKY--TTFNTTPKMSTYLVAFIVADL---RYVESNNFRIPVRVYSTPGDEKFGQFA 229

  Fly   263 NMVVAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGV 327
            ..:.|..|.|:||.||..|...|:|:||:.:|:..:.|||||..:....||.|.:.||:|..|.|
Yeast   230 ANLAARTLRFFEDTFNIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRV 294

  Fly   328 ARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYD 392
            |..:...:.:|||||||::.||..:||...||.::|.:..:..:|||...|::........|:.|
Yeast   295 AEVIQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLD 359

  Fly   393 AHVNTDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSS 457
            :..::..:...|.:...|...::.|...|.:.|..|:.:.:|||.::..:.:||..:....|.:.
Yeast   360 SLRSSHPIEVPVNNADEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTG 424

  Fly   458 DFWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAI-VSQQRFFITPQFRN 521
            |.||.|   .|.:|:     ::..:|..|..:.|:|:::|.   :|:..| ::|.|:..|...:
Yeast   425 DLWDAL---ADASGK-----DVCSVMNIWTKRVGFPVLSVK---EHKNKITLTQHRYLSTGDVK- 477

  Fly   522 RWARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEK----LEAEPTDWILFN 582
                               :..:...:...|....|  :...||::|.:    .|.:..::...|
Yeast   478 -------------------EEEDTTIYPILLALKDS--TGIDNTLVLNEKSATFELKNEEFFKIN 521

  Fly   583 VQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYL 647
            ...:..|..:|....|..|:|      :..|:...:|..||.|..:|:.||.......|.::...
Yeast   522 GDQSGIFITSYSDERWAKLSK------QANLLSVEDRVGLVADAKALSASGYTSTTNFLNLISNW 580

  Fly   648 EHEDEFVVWVATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSGNMTHRPVI 712
            ::||.||||       |:|.|...:..:..:|:               ..|:.::....|...|:
Yeast   581 KNEDSFVVW-------EQIINSLSALKSTWVFE---------------PEDILNALDKFTLDLVL 623

  Fly   713 IRLACEYELPACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKFGTEGDRDMVESMYKRSNFA 777
            .:|:   ||                   ||                 ..|:.|         :||
Yeast   624 NKLS---EL-------------------GW-----------------NIGEDD---------SFA 640

  Fly   778 AE--KESLLTALACSRNVFALQRVLIWTFES-SGVRKQNARRTFKAVVSNSMGYRLAKKYVSVNM 839
            .:  |.:|.:| ||:.....:|.:.:..||. :...||.....|||||.|::. ||..:.   |.
Yeast   641 IQRLKVTLFSA-ACTSGNEKMQSIAVEMFEEYANGNKQAIPALFKAVVFNTVA-RLGGEN---NY 700

  Fly   840 QNIRNYCSN---STDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKILLERG--N 899
            :.|.|...|   |.:|::.|           :.|..|..  ||:|      ||.:..||:..  |
Yeast   701 EKIFNIYQNPVSSEEKIIAL-----------RALGRFED--KELL------ERTLSYLLDGTVLN 746

  Fly   900 DNIHWQRTKFRPMLQAIRDIILWRSR-----AKRI 929
            .:.:......|...:.|..:..|...     |||:
Yeast   747 QDFYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRL 781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	M1_APN-Q_like	33..487	CDD:341064	134/476 (28%)
		ERAP1_C	578..897	CDD:463368	71/324 (22%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	135/477 (28%)
		ERAP1_C	517..833	CDD:463368	78/365 (21%)