DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and LAP2

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_014353.1	Gene:	LAP2 / 855682	SGDID:	S000004990	Length:	671	Species:	Saccharomyces cerevisiae

Alignment Length:	579	Identity:	127/579 - (21%)
Similarity:	219/579 - (37%)	Gaps:	140/579 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 KRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNT---TLTQWLAA-----------TQFEPN 161
            |.||      ..|:...:...|||   ::.|.....|   |..|||.:           :|.|..
Yeast   133 KEPL------GSRLVINNASCNDN---FTLNIQFRTTDKCTALQWLNSKQTKGGKPYVFSQLEAI 188

  Fly   162 HAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQFVESHPMQTYLVA 226
            |||..|||||.|..::.|..::..| |....|.:.::.|.:..::     .:|.:..|:..||:
Yeast   189 HARSLFPCFDTPSVKSTFTASIESP-LPVVFSGIRIEDTSKDTNI-----YRFEQKVPIPAYLI- 246

  Fly   227 FMISKFDRPGFTSSERSDCPI----STWARPDALS--QTEFANMVVAPLLSFYEDLFNSTYRQKK 285
                     |..|.:.|..||    :.:..|..|.  |.||.|.|...:.:..:.:|...:....
Yeast   247 ---------GIASGDLSSAPIGPRSTVYTEPFRLKDCQWEFENDVEKFIQTAEKIIFEYEWGTYD 302

  Fly   286 IDLVALPDFTFKSKENWGLPAFAEESLL-YDSQRSSIDDQQGVARAVAMMVVNQWFGNLVSVAWW 349
            | ||.:..:.:...|:..: .||..:|: :|  ||:||       .:|..:.:.|.||||:...|
Yeast   303 I-LVNVDSYPYGGMESPNM-TFATPTLIAHD--RSNID-------VIAHELAHSWSGNLVTNCSW 356

  Fly   350 HEIWLKNVFALYLSRFGVHSLRPE----------W-DYQ---------ERHALQLYLSVLDYDAH 394
            :..||...:.:||.|..:.::..|          | |.|         ||      .|.|..:.:
Yeast   357 NHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQNSIDSMKDPER------FSTLVQNLN 415

  Fly   395 VNTDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTA-LRRYLVVYANRTATSSD 458
            .|||      ||:     |::.:...|...|...|..::|.:|.... :|.|...:|.::..:..
Yeast   416 DNTD------PDD-----AFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQ 469

  Fly   459 FWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYP----LVTVTRNYDHRTA---IVSQQRFFIT 516
            |.|.|.........:...::    .:.||.:||.|    .:|...:..::.|   :...|....|
Yeast   470 FLDTLYEFYPEKKEILDSVD----WETWLYKPGMPPRPHFITALADNVYQLADKWVEMAQHLKTT 530

  Fly   517 PQFRNRWARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILF 581
            ..||:.:.         :........::::.|...||     .:..||.      :.:..||..|
Yeast   531 EDFRSEFN---------AIDIKDFNSNQLVLFLETLT-----QNGHSNK------KPKDFDWAKF 575

  Fly   582 NVQHTAPFRVNYD----LRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLA-WSGDI 635
            .|...|...:..|    .:|.:::.|..    ||::.     |:|.::...|| |.|.:
Yeast   576 PVASRALLDIYQDNIVKSQNAEVVFKMF----KFQIF-----AKLQEEYKHLADWLGTV 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	84/350 (24%)
		M1_APN_2	33..493	CDD:189008	99/423 (23%)
		ERAP1_C	579..897	CDD:288671	14/62 (23%)
LAP2	NP_014353.1	leuko_A4_hydro	57..669	CDD:274120	127/579 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810